Minimal inter-fractional fiducial migration during image-guided lung stereotactic body radiotherapy using super lock nitinol coil fiducial markers

Yi Rong, Jose G. Bazan, Ashley Sekhon, Karl Haglund, Meng Xu-Welliver, Terence Williams

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives Stereotactic body radiotherapy (SBRT) is being increasingly used for the treatment of patients with lung cancer or lung metastasis who are medically unfit to undergo resection. In order to improve accuracy and confidence in targeting tumors, many centers rely on fiducial implantation. We evaluated the migration of a novel fiducial marker specifically designed for lung tissue implanted via electromagnetic navigation bronchoscopy (ENB). Methods We retrospectively quantified the individual and group migrations of SuperLock nitinol coil fiducials for 15 patients receiving lung stereotactic body radiotherapy (SBRT), in order to evaluate the reliability of using these fiducials as a target surrogate for cases where tumors cannot be clearly delineated on cone beam CTs (CBCTs). For each fraction, we compared the individual and group migrations of the fiducials between the planning CT and the acquired CBCT. The group migration was defined as the distance between the centroids of the fiducial group and GTV. Results A total of 16 lung targets were included in our study for these 15 patients (one patient with two targets). Of 55 fiducials placed, we observed a 100% retention rate. The mean individual migration was 1.87 mm (range, 0.63-5.25 mm) with a standard deviation of 1.26 mm. The mean group migration was 1.94 mm (range, 0.03-6.19 mm) with a standard deviation of 1.45 mm. Overall, there was minimal change in the relative locations of the markers with respect to each other, as well as to the target. Conclusions We found that the SuperLock nitinol coil fiducial marker positions are stable throughout the radiation treatment, and can be used as a reliable surrogate to target, and to avoid geometric misses during gated treatments.

Original languageEnglish (US)
Article numbere0131945
JournalPLoS One
Volume10
Issue number7
DOIs
StatePublished - Jul 9 2015

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Fiducial Markers
Radiosurgery
Radiotherapy
radiotherapy
Cones
Tumors
lungs
Lung
Lung Neoplasms
Navigation
Tissue
bronchoscopy
Radiation
Planning
neoplasms
Cone-Beam Computed Tomography
Electromagnetic Phenomena
Bronchoscopy
resection
lung neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Minimal inter-fractional fiducial migration during image-guided lung stereotactic body radiotherapy using super lock nitinol coil fiducial markers. / Rong, Yi; Bazan, Jose G.; Sekhon, Ashley; Haglund, Karl; Xu-Welliver, Meng; Williams, Terence.

In: PLoS One, Vol. 10, No. 7, e0131945, 09.07.2015.

Research output: Contribution to journalArticle

Rong, Yi ; Bazan, Jose G. ; Sekhon, Ashley ; Haglund, Karl ; Xu-Welliver, Meng ; Williams, Terence. / Minimal inter-fractional fiducial migration during image-guided lung stereotactic body radiotherapy using super lock nitinol coil fiducial markers. In: PLoS One. 2015 ; Vol. 10, No. 7.
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abstract = "Objectives Stereotactic body radiotherapy (SBRT) is being increasingly used for the treatment of patients with lung cancer or lung metastasis who are medically unfit to undergo resection. In order to improve accuracy and confidence in targeting tumors, many centers rely on fiducial implantation. We evaluated the migration of a novel fiducial marker specifically designed for lung tissue implanted via electromagnetic navigation bronchoscopy (ENB). Methods We retrospectively quantified the individual and group migrations of SuperLock nitinol coil fiducials for 15 patients receiving lung stereotactic body radiotherapy (SBRT), in order to evaluate the reliability of using these fiducials as a target surrogate for cases where tumors cannot be clearly delineated on cone beam CTs (CBCTs). For each fraction, we compared the individual and group migrations of the fiducials between the planning CT and the acquired CBCT. The group migration was defined as the distance between the centroids of the fiducial group and GTV. Results A total of 16 lung targets were included in our study for these 15 patients (one patient with two targets). Of 55 fiducials placed, we observed a 100{\%} retention rate. The mean individual migration was 1.87 mm (range, 0.63-5.25 mm) with a standard deviation of 1.26 mm. The mean group migration was 1.94 mm (range, 0.03-6.19 mm) with a standard deviation of 1.45 mm. Overall, there was minimal change in the relative locations of the markers with respect to each other, as well as to the target. Conclusions We found that the SuperLock nitinol coil fiducial marker positions are stable throughout the radiation treatment, and can be used as a reliable surrogate to target, and to avoid geometric misses during gated treatments.",
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