Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning

Yang Lv, Xinyu Lv, Weiping Liu, Martin S. Judenhofer, Allison Zwingenberger, Erik R Wisner, Eric Berg, Sarah McKenney, Edwin Leung, Benjamin A. Spencer, Simon R Cherry, Ramsey D Badawi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

As part of the EXPLORER total-body positron emission tomography (PET) project, we have designed and built a high-resolution, high-sensitivity PET/CT scanner, which is expected to have excellent performance for companion animal whole body and human brain imaging. The PET component has a ring diameter of 52 cm and an axial field of view of 48.3 cm. The detector modules are composed of arrays of lutetium (yttrium) oxyorthosilicate (LYSO) crystals of dimensions 2.76  ×  2.76  ×  18.1 mm3 coupled to silicon photomultipliers (SiPMs) for read-out. The CT component is a 24 detector row CT scanner with a 50 kW x-ray tube. PET system time-of-flight resolution was measured to be 409  ±  39 ps and average system energy resolution was 11.7%  ±  1.5% at 511 keV. The NEMA NU2-2012 system sensitivity was found to be 52-54 kcps MBq-1. Spatial resolution was 2.6 mm at 10 mm from the center of the FOV and 2.0 mm rods were clearly resolved on a mini-Derenzo phantom. Peak noise-equivalent count (NEC) rate, using the NEMA NU 2-2012 phantom, was measured to be 314 kcps at 9.2 kBq cc-1. The CT scanner passed the technical components of the American College of Radiology (ACR) accreditation tests. We have also performed scans of a Hoffman brain phantom and we show images from the first canine patient imaged on this device.

Original languageEnglish (US)
Number of pages1
JournalPhysics in medicine and biology
Volume64
Issue number7
DOIs
StatePublished - Mar 21 2019

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Pets
Human Body
Positron-Emission Tomography
Brain
Yttrium
Accreditation
Silicon
Radiology
Neuroimaging
Noise
Canidae
X-Rays
Equipment and Supplies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Mini EXPLORER II : a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning. / Lv, Yang; Lv, Xinyu; Liu, Weiping; Judenhofer, Martin S.; Zwingenberger, Allison; Wisner, Erik R; Berg, Eric; McKenney, Sarah; Leung, Edwin; Spencer, Benjamin A.; Cherry, Simon R; Badawi, Ramsey D.

In: Physics in medicine and biology, Vol. 64, No. 7, 21.03.2019.

Research output: Contribution to journalArticle

Lv, Yang ; Lv, Xinyu ; Liu, Weiping ; Judenhofer, Martin S. ; Zwingenberger, Allison ; Wisner, Erik R ; Berg, Eric ; McKenney, Sarah ; Leung, Edwin ; Spencer, Benjamin A. ; Cherry, Simon R ; Badawi, Ramsey D. / Mini EXPLORER II : a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning. In: Physics in medicine and biology. 2019 ; Vol. 64, No. 7.
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