Mineral status of mice suckling early-, mid- and late-lactating foster dams

B. L. Reis, Carl L Keen, B. Lonnerdal, L. S. Hurley

Research output: Contribution to journalArticle

Abstract

We have demonstrated that the zinc (Zn) concentration of mouse milk declines significantly over the lactation period. Pups radiolabeled in utero with 65Zn were forward-fostered (FF) to nonradiolabeled dams at a later stage of lactation to study the effects of early milk deprivation. Other groups of radiolabeled pups were back-fostered at 5, 10 and 15 days of age to a nonradiolabeled dam who had just given birth; this provided additional colostrum during the suckling period. Litters fostered at birth to an unlabeled dam at d 0 of lactation were used as controls. Weight gain of FF litters decreased and signs of Zn deficiency increased as the foster dam's days of lactation increased. The Zn concentration of kidney, brain and plasma tended to decrease with increasing lactation days of the foster dam. Tibia Zn concentration declined progressively as the lactation days of the foster dam increased, and the concentration of calcium also was lower in all three groups of FF litters than in controls, indicating that bone calcification may have been impaired. Kinetic data proved to be a more sensitive index of Zn status than tissue Zn concentration. The biological half-life of whole-body 65Zn for FF suckling mice increased in a linear fashion with increasing lactation days of the foster dam; whole-body retention of 65Zn for back-fostered litters did not differ from that for controls. Brain, small intestine, kidney, muscle, plasma and tibia of pups FF to late-lactating dams seemed to have greater retention of Zn than did controls. Thus, deprivation of early milk impaired growth and development of the mouse neonate despite some ability to conserve Zn.

Original languageEnglish (US)
Pages (from-to)700-710
Number of pages11
JournalJournal of Nutrition
Volume121
Issue number5
StatePublished - 1991

Fingerprint

suckling
Minerals
Zinc
Lactation
zinc
minerals
lactation
mice
litters (young animals)
pups
Milk
tibia
Tibia
milk
kidneys
Parturition
biological half-life
Kidney
brain
bone mineralization

Keywords

  • Zn
  • Development
  • Mice
  • Trace elements
  • Zinc

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Reis, B. L., Keen, C. L., Lonnerdal, B., & Hurley, L. S. (1991). Mineral status of mice suckling early-, mid- and late-lactating foster dams. Journal of Nutrition, 121(5), 700-710.

Mineral status of mice suckling early-, mid- and late-lactating foster dams. / Reis, B. L.; Keen, Carl L; Lonnerdal, B.; Hurley, L. S.

In: Journal of Nutrition, Vol. 121, No. 5, 1991, p. 700-710.

Research output: Contribution to journalArticle

Reis, BL, Keen, CL, Lonnerdal, B & Hurley, LS 1991, 'Mineral status of mice suckling early-, mid- and late-lactating foster dams', Journal of Nutrition, vol. 121, no. 5, pp. 700-710.
Reis BL, Keen CL, Lonnerdal B, Hurley LS. Mineral status of mice suckling early-, mid- and late-lactating foster dams. Journal of Nutrition. 1991;121(5):700-710.
Reis, B. L. ; Keen, Carl L ; Lonnerdal, B. ; Hurley, L. S. / Mineral status of mice suckling early-, mid- and late-lactating foster dams. In: Journal of Nutrition. 1991 ; Vol. 121, No. 5. pp. 700-710.
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