Mineral homeostasis in young children consuming typical U.S. diets

Ian J. Griffin, M. Fran Lynch, Keli M. Hawthorne, Steven A. Abrams

Research output: Contribution to journalArticle

Abstract

Mineral requirements in young children are poorly understood, and current recommendations rely heavily on data collected in older children or adults. Our objectives were to assess the relationship between mineral (Ca, Mg, Fe, Zn, and Cu) intake in young U.S. children, and mineral absorption, excretion, and retention; and to use these data to re-examine the most recent recommended intakes. Thirty children, 1-4 y old, were studied on their usual diet. After 7 d of home adaptation they were admitted for either a 2-d or 5-d metabolic study where multiple stable isotope or Ca, Mg, Fe, Zn, and Cu were administered and mineral absorption (2-d study), or absorption and excretion (5-d study) were assessed. Fractional (%) absorption of some (Ca, Mg) but not all (Fe, Zn) minerals decreased as intake increased. Absolute (total) absorption and net retention of all the minerals increased as their intake increased. Mineral homeostasis was related to changes in fractional absorption (Ca and Mg), fecal excretion (Zn), or whole body mineral status (Fe). Our results support the current U.S. recommended intakes for 1-4-y-old children for Mg and Fe, but suggest that those for Ca and Zn are too low.

Original languageEnglish (US)
Pages (from-to)437-445
Number of pages9
JournalPure and Applied Chemistry
Volume82
Issue number2
DOIs
StatePublished - 2010

Fingerprint

Nutrition
Minerals
Isotopes

Keywords

  • Calcium
  • Copper
  • Iron
  • Magnesium
  • Mineral absorption
  • Mineral balance
  • Mineral excretion
  • Mineral homeostasis
  • Stable isotope
  • Zinc

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Griffin, I. J., Fran Lynch, M., Hawthorne, K. M., & Abrams, S. A. (2010). Mineral homeostasis in young children consuming typical U.S. diets. Pure and Applied Chemistry, 82(2), 437-445. https://doi.org/10.1351/PAC-CON-09-06-07

Mineral homeostasis in young children consuming typical U.S. diets. / Griffin, Ian J.; Fran Lynch, M.; Hawthorne, Keli M.; Abrams, Steven A.

In: Pure and Applied Chemistry, Vol. 82, No. 2, 2010, p. 437-445.

Research output: Contribution to journalArticle

Griffin, IJ, Fran Lynch, M, Hawthorne, KM & Abrams, SA 2010, 'Mineral homeostasis in young children consuming typical U.S. diets', Pure and Applied Chemistry, vol. 82, no. 2, pp. 437-445. https://doi.org/10.1351/PAC-CON-09-06-07
Griffin, Ian J. ; Fran Lynch, M. ; Hawthorne, Keli M. ; Abrams, Steven A. / Mineral homeostasis in young children consuming typical U.S. diets. In: Pure and Applied Chemistry. 2010 ; Vol. 82, No. 2. pp. 437-445.
@article{002f35ce128741869fb1f744a3eba5ff,
title = "Mineral homeostasis in young children consuming typical U.S. diets",
abstract = "Mineral requirements in young children are poorly understood, and current recommendations rely heavily on data collected in older children or adults. Our objectives were to assess the relationship between mineral (Ca, Mg, Fe, Zn, and Cu) intake in young U.S. children, and mineral absorption, excretion, and retention; and to use these data to re-examine the most recent recommended intakes. Thirty children, 1-4 y old, were studied on their usual diet. After 7 d of home adaptation they were admitted for either a 2-d or 5-d metabolic study where multiple stable isotope or Ca, Mg, Fe, Zn, and Cu were administered and mineral absorption (2-d study), or absorption and excretion (5-d study) were assessed. Fractional ({\%}) absorption of some (Ca, Mg) but not all (Fe, Zn) minerals decreased as intake increased. Absolute (total) absorption and net retention of all the minerals increased as their intake increased. Mineral homeostasis was related to changes in fractional absorption (Ca and Mg), fecal excretion (Zn), or whole body mineral status (Fe). Our results support the current U.S. recommended intakes for 1-4-y-old children for Mg and Fe, but suggest that those for Ca and Zn are too low.",
keywords = "Calcium, Copper, Iron, Magnesium, Mineral absorption, Mineral balance, Mineral excretion, Mineral homeostasis, Stable isotope, Zinc",
author = "Griffin, {Ian J.} and {Fran Lynch}, M. and Hawthorne, {Keli M.} and Abrams, {Steven A.}",
year = "2010",
doi = "10.1351/PAC-CON-09-06-07",
language = "English (US)",
volume = "82",
pages = "437--445",
journal = "Pure and Applied Chemistry",
issn = "0033-4545",
publisher = "IUPAC Secretariat",
number = "2",

}

TY - JOUR

T1 - Mineral homeostasis in young children consuming typical U.S. diets

AU - Griffin, Ian J.

AU - Fran Lynch, M.

AU - Hawthorne, Keli M.

AU - Abrams, Steven A.

PY - 2010

Y1 - 2010

N2 - Mineral requirements in young children are poorly understood, and current recommendations rely heavily on data collected in older children or adults. Our objectives were to assess the relationship between mineral (Ca, Mg, Fe, Zn, and Cu) intake in young U.S. children, and mineral absorption, excretion, and retention; and to use these data to re-examine the most recent recommended intakes. Thirty children, 1-4 y old, were studied on their usual diet. After 7 d of home adaptation they were admitted for either a 2-d or 5-d metabolic study where multiple stable isotope or Ca, Mg, Fe, Zn, and Cu were administered and mineral absorption (2-d study), or absorption and excretion (5-d study) were assessed. Fractional (%) absorption of some (Ca, Mg) but not all (Fe, Zn) minerals decreased as intake increased. Absolute (total) absorption and net retention of all the minerals increased as their intake increased. Mineral homeostasis was related to changes in fractional absorption (Ca and Mg), fecal excretion (Zn), or whole body mineral status (Fe). Our results support the current U.S. recommended intakes for 1-4-y-old children for Mg and Fe, but suggest that those for Ca and Zn are too low.

AB - Mineral requirements in young children are poorly understood, and current recommendations rely heavily on data collected in older children or adults. Our objectives were to assess the relationship between mineral (Ca, Mg, Fe, Zn, and Cu) intake in young U.S. children, and mineral absorption, excretion, and retention; and to use these data to re-examine the most recent recommended intakes. Thirty children, 1-4 y old, were studied on their usual diet. After 7 d of home adaptation they were admitted for either a 2-d or 5-d metabolic study where multiple stable isotope or Ca, Mg, Fe, Zn, and Cu were administered and mineral absorption (2-d study), or absorption and excretion (5-d study) were assessed. Fractional (%) absorption of some (Ca, Mg) but not all (Fe, Zn) minerals decreased as intake increased. Absolute (total) absorption and net retention of all the minerals increased as their intake increased. Mineral homeostasis was related to changes in fractional absorption (Ca and Mg), fecal excretion (Zn), or whole body mineral status (Fe). Our results support the current U.S. recommended intakes for 1-4-y-old children for Mg and Fe, but suggest that those for Ca and Zn are too low.

KW - Calcium

KW - Copper

KW - Iron

KW - Magnesium

KW - Mineral absorption

KW - Mineral balance

KW - Mineral excretion

KW - Mineral homeostasis

KW - Stable isotope

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=77749317192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749317192&partnerID=8YFLogxK

U2 - 10.1351/PAC-CON-09-06-07

DO - 10.1351/PAC-CON-09-06-07

M3 - Article

AN - SCOPUS:77749317192

VL - 82

SP - 437

EP - 445

JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

SN - 0033-4545

IS - 2

ER -