Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones

William W. Yuen, Nan R. Du, Chun H. Chan, Eduardo Silva, David J. Mooney

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Nature frequently utilizes opposing factors to create a stable activator gradient to robustly control pattern formation. This study employs a biomimicry approach, by delivery of both angiogenic and antiangiogenic factors from spatially restricted zones of a synthetic polymer to achieve temporally stable and spatially restricted angiogenic zones in vivo. The simultaneous release of the two spatially separated agents leads to a spatially sharp angiogenic region that is sustained over 3 wk. Further, the contradictory action of the two agents leads to a stable level of proangiogenic stimulation in this region, in spite of significant variations in the individual release rates over time. The resulting spatially restrictive and temporally sustained profiles of active signaling allow the creation of a spatially heterogeneous and functional vasculature.

Original languageEnglish (US)
Pages (from-to)17933-17938
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number42
DOIs
StatePublished - Oct 19 2010
Externally publishedYes

Keywords

  • Controlled drug delivery
  • Diffusion reaction
  • Peripheral ischemia
  • Turing pattern
  • VEGF antibody

ASJC Scopus subject areas

  • General

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