Mimicking immune processes by positioning antibodies on surfaces - A nanoengineering approach

Gang-yu Liu; Nabil A. Amro; Vladimir Komanicky; Maozi Liu

Mimicking immune processes by positioning antibodies on surfaces - A nanoengineering approach

Gang-yu Liu, Nabil A. Amro, Vladimir Komanicky, Maozi Liu

Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Antibody-antigen interaction is one of the most fundamental biospecific interactions. While the antibody-antigen monovalent and divalent bindings are relatively well known in solution phase, systematic investigations and control of antigen-antibody interactions on surfaces are still lacking. Using scanning probe nanolithography, antigens such as small ligand groups or proteins can be positioned on surfaces with nanometer precision. Subsequent reactions with specific antibodies result in the formation of antibody-antigen complexes on surfaces. The monovalent and divalent interactions could occur, depending upon the designs of the nanostructures of antigens, and the reaction conditions. Examples and detailed results of this nanoengineering approach will be included in the presentation.

Original language	English (US)
Title of host publication	2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Editors	M. Laudon, B. Romanowicz
Pages	396-399
Number of pages	4
Volume	3
State	Published - 2003
Event	2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States Duration: Feb 23 2003 → Feb 27 2003

Other

Other	2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Country	United States
City	San Francisco, CA
Period	2/23/03 → 2/27/03

Keywords

Antigen-antibody
Interactions
Nanografting
NPRW
Scanning probe lithography

ASJC Scopus subject areas

Engineering(all)

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Cite this

Liu, G., Amro, N. A., Komanicky, V., & Liu, M. (2003). Mimicking immune processes by positioning antibodies on surfaces - A nanoengineering approach. In M. Laudon, & B. Romanowicz (Eds.), 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 (Vol. 3, pp. 396-399)

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abstract = "Antibody-antigen interaction is one of the most fundamental biospecific interactions. While the antibody-antigen monovalent and divalent bindings are relatively well known in solution phase, systematic investigations and control of antigen-antibody interactions on surfaces are still lacking. Using scanning probe nanolithography, antigens such as small ligand groups or proteins can be positioned on surfaces with nanometer precision. Subsequent reactions with specific antibodies result in the formation of antibody-antigen complexes on surfaces. The monovalent and divalent interactions could occur, depending upon the designs of the nanostructures of antigens, and the reaction conditions. Examples and detailed results of this nanoengineering approach will be included in the presentation.",

keywords = "Antigen-antibody, Interactions, Nanografting, NPRW, Scanning probe lithography",

author = "Gang-yu Liu and Amro, {Nabil A.} and Vladimir Komanicky and Maozi Liu",

year = "2003",

language = "English (US)",

isbn = "0972842209",

volume = "3",

pages = "396--399",

editor = "M. Laudon and B. Romanowicz",

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T1 - Mimicking immune processes by positioning antibodies on surfaces - A nanoengineering approach

AU - Liu, Gang-yu

AU - Amro, Nabil A.

AU - Komanicky, Vladimir

AU - Liu, Maozi

PY - 2003

Y1 - 2003

N2 - Antibody-antigen interaction is one of the most fundamental biospecific interactions. While the antibody-antigen monovalent and divalent bindings are relatively well known in solution phase, systematic investigations and control of antigen-antibody interactions on surfaces are still lacking. Using scanning probe nanolithography, antigens such as small ligand groups or proteins can be positioned on surfaces with nanometer precision. Subsequent reactions with specific antibodies result in the formation of antibody-antigen complexes on surfaces. The monovalent and divalent interactions could occur, depending upon the designs of the nanostructures of antigens, and the reaction conditions. Examples and detailed results of this nanoengineering approach will be included in the presentation.

AB - Antibody-antigen interaction is one of the most fundamental biospecific interactions. While the antibody-antigen monovalent and divalent bindings are relatively well known in solution phase, systematic investigations and control of antigen-antibody interactions on surfaces are still lacking. Using scanning probe nanolithography, antigens such as small ligand groups or proteins can be positioned on surfaces with nanometer precision. Subsequent reactions with specific antibodies result in the formation of antibody-antigen complexes on surfaces. The monovalent and divalent interactions could occur, depending upon the designs of the nanostructures of antigens, and the reaction conditions. Examples and detailed results of this nanoengineering approach will be included in the presentation.

KW - Antigen-antibody

KW - Interactions

KW - Nanografting

KW - NPRW

KW - Scanning probe lithography

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M3 - Conference contribution

AN - SCOPUS:6344289338

SN - 0972842209

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EP - 399

BT - 2003 Nanotechnology Conference and Trade Show - Nanotech 2003

A2 - Laudon, M.

A2 - Romanowicz, B.

T2 - 2003 Nanotechnology Conference and Trade Show - Nanotech 2003

Y2 - 23 February 2003 through 27 February 2003

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