Mimicking immune processes by positioning antibodies on surfaces - A nanoengineering approach

Gang-yu Liu, Nabil A. Amro, Vladimir Komanicky, Maozi Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Antibody-antigen interaction is one of the most fundamental biospecific interactions. While the antibody-antigen monovalent and divalent bindings are relatively well known in solution phase, systematic investigations and control of antigen-antibody interactions on surfaces are still lacking. Using scanning probe nanolithography, antigens such as small ligand groups or proteins can be positioned on surfaces with nanometer precision. Subsequent reactions with specific antibodies result in the formation of antibody-antigen complexes on surfaces. The monovalent and divalent interactions could occur, depending upon the designs of the nanostructures of antigens, and the reaction conditions. Examples and detailed results of this nanoengineering approach will be included in the presentation.

Original languageEnglish (US)
Title of host publication2003 Nanotechnology Conference and Trade Show - Nanotech 2003
EditorsM. Laudon, B. Romanowicz
Pages396-399
Number of pages4
Volume3
StatePublished - 2003
Event2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States
Duration: Feb 23 2003Feb 27 2003

Other

Other2003 Nanotechnology Conference and Trade Show - Nanotech 2003
CountryUnited States
CitySan Francisco, CA
Period2/23/032/27/03

Keywords

  • Antigen-antibody
  • Interactions
  • Nanografting
  • NPRW
  • Scanning probe lithography

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Liu, G., Amro, N. A., Komanicky, V., & Liu, M. (2003). Mimicking immune processes by positioning antibodies on surfaces - A nanoengineering approach. In M. Laudon, & B. Romanowicz (Eds.), 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 (Vol. 3, pp. 396-399)