Abstract
Antibody-antigen interaction is one of the most fundamental biospecific interactions. While the antibody-antigen monovalent and divalent bindings are relatively well known in solution phase, systematic investigations and control of antigen-antibody interactions on surfaces are still lacking. Using scanning probe nanolithography, antigens such as small ligand groups or proteins can be positioned on surfaces with nanometer precision. Subsequent reactions with specific antibodies result in the formation of antibody-antigen complexes on surfaces. The monovalent and divalent interactions could occur, depending upon the designs of the nanostructures of antigens, and the reaction conditions. Examples and detailed results of this nanoengineering approach will be included in the presentation.
Original language | English (US) |
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Title of host publication | 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 |
Editors | M. Laudon, B. Romanowicz |
Pages | 396-399 |
Number of pages | 4 |
Volume | 3 |
State | Published - 2003 |
Event | 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States Duration: Feb 23 2003 → Feb 27 2003 |
Other
Other | 2003 Nanotechnology Conference and Trade Show - Nanotech 2003 |
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Country/Territory | United States |
City | San Francisco, CA |
Period | 2/23/03 → 2/27/03 |
Keywords
- Antigen-antibody
- Interactions
- Nanografting
- NPRW
- Scanning probe lithography
ASJC Scopus subject areas
- Engineering(all)