Milrinone effects in the isolated immature rabbit heart

Mark D Parrish, T. S. Brannon, A. Payne, N. Ayres, D. E. Fixler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Milrinone, a new positive inotropic agent, was evaluated and compared to isoproterenol in an immature isolated isovolumic rabbit heart model. Three age groups were studied: newborns (0-6 days), juveniles (4-6 weeks old) and adults (5-7 months old). Heart rate did not change significantly with milrinone or isoproterenol in adults or juveniles, but increased in newborns from 144 ± 1 to 162 ± (SEM) 6 beats/min at peak milrinone effect. Milrinone had a greater effect on the contractility (maximum positive dP/dt) of the mature hearts, with newborns increasing to 134 ± 6% of baseline, juveniles to 154 ± 8% and adults to 216 ± 15%. Results were similar for isoproterenol, although the positive inotropic effect occurred over a wider dosage range for this drug. No additive effects of the two drugs were noted. We conclude, that although milrinone is a positive inotropic drug in all age groups studied, the response of the newborn heart is quantitatively much weaker than that of the adult.

Original languageEnglish (US)
Pages (from-to)328-337
Number of pages10
JournalDevelopmental Pharmacology and Therapeutics
Volume11
Issue number6
StatePublished - 1988
Externally publishedYes

Fingerprint

Milrinone
Rabbits
Isoproterenol
Newborn Infant
Age Groups
Pharmaceutical Preparations
Heart Rate

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Parrish, M. D., Brannon, T. S., Payne, A., Ayres, N., & Fixler, D. E. (1988). Milrinone effects in the isolated immature rabbit heart. Developmental Pharmacology and Therapeutics, 11(6), 328-337.

Milrinone effects in the isolated immature rabbit heart. / Parrish, Mark D; Brannon, T. S.; Payne, A.; Ayres, N.; Fixler, D. E.

In: Developmental Pharmacology and Therapeutics, Vol. 11, No. 6, 1988, p. 328-337.

Research output: Contribution to journalArticle

Parrish, MD, Brannon, TS, Payne, A, Ayres, N & Fixler, DE 1988, 'Milrinone effects in the isolated immature rabbit heart', Developmental Pharmacology and Therapeutics, vol. 11, no. 6, pp. 328-337.
Parrish, Mark D ; Brannon, T. S. ; Payne, A. ; Ayres, N. ; Fixler, D. E. / Milrinone effects in the isolated immature rabbit heart. In: Developmental Pharmacology and Therapeutics. 1988 ; Vol. 11, No. 6. pp. 328-337.
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