Mild cognitive impairment and alzheimer disease

Patterns of altered cerebral blood flow at MR imaging

Weiying Dai, Oscar L. Lopez, Owen T. Carmichael, James T. Becker, Lewis H. Kuller, H. Michael Gach

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

Purpose: To examine regional cerebral blood flow (rCBF) in incidentmild cognitive impairment (MCI) and Alzheimer disease (AD) by using continuous arterial spin-labeling (CASL) magnetic resonance (MR) imaging. Materials and Methods: This study was approved by the local institutional review board and was compliant with HIPAA regulations. In formed consent was obtained. rCBF was measured in 38 control subjects, 29 MCI patients, and 37 AD patients who were participating in a longitudinal epidemiologic study. Multisection CASL MR imaging with alternating single and double adiabatic inversion pulses and ramp-sampled echo-planar imaging were performed to acquire 19 contiguous axial sections. Voxel-level rCBF was compared among groups by using an analysis of variance design; clusters of voxels with significant group differences were identified. Multiple regression models controlled for age, sex, and presence of hypertension and related the mean rCBF in those clusters to the presence of MCI and AD.Results: MCI and AD patients had decreased rCBF in the posterior cingulate gyrus (P = .01) with extension to the medial precuneus compared with that in control subjects. MCI patients had increased rCBF in the left hippocampus (P < .001), right amygdala (P = .007), and rostral head of the right caudate nucleus and ventral putamen and globus pallidus (P = .003) compared with that in control subjects. AD patients had decreased rCBF relative to that in control subjects and MCI patients in the left inferior parietal (P = .005), left lateral frontal (P < .001), left superior temporal (P = .001), and left orbitofrontal (P = .003) cortices. AD patients had increased rCBF in the right anterior cingulate gyrus ( P = .02) compared with that in control subjects. Conclusion: The transition from normal cognition to AD is associated with dynamic pathologic processes in the brain, and this is reflected by both decreases and increases in rCBF. In creases in rCBF suggest a cellular and vascular compensatory process associated with incipient AD.

Original languageEnglish (US)
Pages (from-to)856-866
Number of pages11
JournalRadiology
Volume250
Issue number3
DOIs
StatePublished - Mar 2009

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Cerebrovascular Circulation
Regional Blood Flow
Alzheimer Disease
Magnetic Resonance Imaging
Gyrus Cinguli
Cognitive Dysfunction
Echo-Planar Imaging
Health Insurance Portability and Accountability Act
Parietal Lobe
Architectural Accessibility
Globus Pallidus
Caudate Nucleus
Research Ethics Committees
Putamen
Pathologic Processes
Amygdala
Cognition
Blood Vessels
Longitudinal Studies
Epidemiologic Studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Dai, W., Lopez, O. L., Carmichael, O. T., Becker, J. T., Kuller, L. H., & Gach, H. M. (2009). Mild cognitive impairment and alzheimer disease: Patterns of altered cerebral blood flow at MR imaging. Radiology, 250(3), 856-866. https://doi.org/10.1148/radiol.2503080751

Mild cognitive impairment and alzheimer disease : Patterns of altered cerebral blood flow at MR imaging. / Dai, Weiying; Lopez, Oscar L.; Carmichael, Owen T.; Becker, James T.; Kuller, Lewis H.; Gach, H. Michael.

In: Radiology, Vol. 250, No. 3, 03.2009, p. 856-866.

Research output: Contribution to journalArticle

Dai, W, Lopez, OL, Carmichael, OT, Becker, JT, Kuller, LH & Gach, HM 2009, 'Mild cognitive impairment and alzheimer disease: Patterns of altered cerebral blood flow at MR imaging', Radiology, vol. 250, no. 3, pp. 856-866. https://doi.org/10.1148/radiol.2503080751
Dai, Weiying ; Lopez, Oscar L. ; Carmichael, Owen T. ; Becker, James T. ; Kuller, Lewis H. ; Gach, H. Michael. / Mild cognitive impairment and alzheimer disease : Patterns of altered cerebral blood flow at MR imaging. In: Radiology. 2009 ; Vol. 250, No. 3. pp. 856-866.
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