Migration and function of glia in the developing Drosophila eye

Radha Rangarajan, Qizhi Gong, Ulrike Gaul

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Although glial cells have been implicated widely in the formation of axon tracts in both insects and vertebrates, their specific function appears to be context-dependent, ranging from providing essential guidance cues to playing a merely facilitory role. Here we examine the role of the retinal basal glia (RBG) in photoreceptor axon guidance in Drosophila. The RBG originate in the optic stalk and have been thought to migrate into the eye disc along photoreceptor axons, thus precluding any role in axon guidance. Here we show the following. (1) The RBG can, in fact, migrate into the eye disc even in the absence of photoreceptor axons in the optic stalk; they also migrate to ectopic patches of differentiating photoreceptors without axons providing a continuous physical substratum. This suggests that glial cells are attracted into the eye disc not through haptotaxis along established axons, but through another mechanism, possibly chemotaxis. (2) If no glial cells are present in the eye disc, photoreceptor axons are able to grow and direct their growth posteriorly as in wild type, but are unable to enter the optic stalk. This indicates that the RBG have a crucial role in axon guidance, but not in axonal outgrowth per se. (3) A few glia close to the entry of the optic stalk suffice to guide the axons into the stalk, suggesting that glia instruct axons by local interaction.

Original languageEnglish (US)
Pages (from-to)3285-3292
Number of pages8
JournalDevelopment
Volume126
Issue number15
StatePublished - Aug 1999
Externally publishedYes

Keywords

  • Axon guidance
  • Drosophila
  • Glia
  • Migration
  • Visual system development

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Fingerprint Dive into the research topics of 'Migration and function of glia in the developing Drosophila eye'. Together they form a unique fingerprint.

  • Cite this

    Rangarajan, R., Gong, Q., & Gaul, U. (1999). Migration and function of glia in the developing Drosophila eye. Development, 126(15), 3285-3292.