Abstract
Background: Cervical preparation is recommended before second-trimester abortion. We investigated the use of a pharmacologic method of preparation, mifepristone, as compared to osmotic dilators for surgical abortions at 14-16 weeks. Study Design: This was a randomized, parallel-group study with concealed allocation. Women were allocated to receive osmotic dilators or mifepristone 200 mg orally 24 h prior to abortion. The study population was 50 women seeking surgical abortion at 14-16 menstrual weeks in a hospital-based abortion service. The primary outcome was the length of time to perform the procedure; the study had 80% power to detect a difference of more than 3 min in procedure time. Secondary outcomes included cervical dilation, side effects and acceptability. Results: The mean abortion time for the osmotic dilator group was 8.00 min [95% confidence interval (CI) 6.75-11.47], and that for the mifepristone group was 9.87 min (95% CI 8.93-11.36). Side effects of pain were more common in the osmotic dilator group. Conclusion: Mifepristone did not increase the time for abortion by more than the prespecified margin (3 min). Women preferred mifepristone to osmotic dilators.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 567-571 |
| Number of pages | 5 |
| Journal | Contraception |
| Volume | 86 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 2012 |
| Externally published | Yes |
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Keywords
- Abortion
- Cervical priming
- Laminaria
- Mifepristone
- Osmotic dilators
- Second trimester
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology
Cite this
Mifepristone vs. osmotic dilator insertion for cervical preparation prior to surgical abortion at 14-16 weeks : A randomized trial. / Borgatta, Lynn; Roncari, Danielle; Sonalkar, Sarita; Mark, Alice; Hou, Melody; Finneseth, Molly; Vragovic, Olivera.
In: Contraception, Vol. 86, No. 5, 11.2012, p. 567-571.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mifepristone vs. osmotic dilator insertion for cervical preparation prior to surgical abortion at 14-16 weeks
T2 - A randomized trial
AU - Borgatta, Lynn
AU - Roncari, Danielle
AU - Sonalkar, Sarita
AU - Mark, Alice
AU - Hou, Melody
AU - Finneseth, Molly
AU - Vragovic, Olivera
PY - 2012/11
Y1 - 2012/11
N2 - Background: Cervical preparation is recommended before second-trimester abortion. We investigated the use of a pharmacologic method of preparation, mifepristone, as compared to osmotic dilators for surgical abortions at 14-16 weeks. Study Design: This was a randomized, parallel-group study with concealed allocation. Women were allocated to receive osmotic dilators or mifepristone 200 mg orally 24 h prior to abortion. The study population was 50 women seeking surgical abortion at 14-16 menstrual weeks in a hospital-based abortion service. The primary outcome was the length of time to perform the procedure; the study had 80% power to detect a difference of more than 3 min in procedure time. Secondary outcomes included cervical dilation, side effects and acceptability. Results: The mean abortion time for the osmotic dilator group was 8.00 min [95% confidence interval (CI) 6.75-11.47], and that for the mifepristone group was 9.87 min (95% CI 8.93-11.36). Side effects of pain were more common in the osmotic dilator group. Conclusion: Mifepristone did not increase the time for abortion by more than the prespecified margin (3 min). Women preferred mifepristone to osmotic dilators.
AB - Background: Cervical preparation is recommended before second-trimester abortion. We investigated the use of a pharmacologic method of preparation, mifepristone, as compared to osmotic dilators for surgical abortions at 14-16 weeks. Study Design: This was a randomized, parallel-group study with concealed allocation. Women were allocated to receive osmotic dilators or mifepristone 200 mg orally 24 h prior to abortion. The study population was 50 women seeking surgical abortion at 14-16 menstrual weeks in a hospital-based abortion service. The primary outcome was the length of time to perform the procedure; the study had 80% power to detect a difference of more than 3 min in procedure time. Secondary outcomes included cervical dilation, side effects and acceptability. Results: The mean abortion time for the osmotic dilator group was 8.00 min [95% confidence interval (CI) 6.75-11.47], and that for the mifepristone group was 9.87 min (95% CI 8.93-11.36). Side effects of pain were more common in the osmotic dilator group. Conclusion: Mifepristone did not increase the time for abortion by more than the prespecified margin (3 min). Women preferred mifepristone to osmotic dilators.
KW - Abortion
KW - Cervical priming
KW - Laminaria
KW - Mifepristone
KW - Osmotic dilators
KW - Second trimester
UR - http://www.scopus.com/inward/record.url?scp=84867092189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867092189&partnerID=8YFLogxK
U2 - 10.1016/j.contraception.2012.05.002
DO - 10.1016/j.contraception.2012.05.002
M3 - Article
C2 - 22682721
AN - SCOPUS:84867092189
VL - 86
SP - 567
EP - 571
JO - Contraception
JF - Contraception
SN - 0010-7824
IS - 5
ER -