Mifepristone followed on the same day by vaginal misoprostol for early abortion

H. C. Pymar, Mitchell D Creinin, J. L. Schwartz

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

We performed a pilot study to examine the clinical efficacy of mifepristone 200 mg followed on the same day by misoprostol 800 μg vaginally in women with pregnancies up to 49 days gestation. Forty women received mifepristone 200 mg after which they self-inserted misoprostol intravaginally 6 to 8 h later at home. Participants returned for an evaluation, including transvaginal ultrasonography, 24 ± 1 h after using the misoprostol. Participants who had not aborted received a second dose of misoprostol to administer 48 h after the mifepristone. All participants returned approximately 2 weeks after receiving mifepristone. At 24 h after receiving misoprostol, 37/40 (92%, 95% CI 81-98%) had ultrasonographic evidence of complete abortion. By follow-up 2 weeks after the mifepristone, 40/40 (100%, 95% CI 92-100%) women were felt to have complete abortions. One subject subsequently had a suction aspiration for an incomplete abortion on study Day 44. Nausea, vomiting, diarrhea, and warmth/chills occurred in 38%, 13%, 13%, and 60%, respectively. This pilot study suggests that mifepristone 200 mg, followed on the same day by misoprostol 800 μg vaginally, effects abortion at rates comparable to regimens using the standard time interval of 48 h between medications.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalContraception
Volume64
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Abortion
  • Medical abortion
  • Mifepristone
  • Misoprostol

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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