Mifepristone and misoprostol for the treatment of early pregnancy failure: a pilot clinical trial

Courtney A. Schreiber, Mitchell D Creinin, Matthew F. Reeves, Bryna J. Harwood

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background: In an attempt to improve efficacy for women who desire medical management of early pregnancy failure (EPF), we studied the efficacy and acceptability of mifepristone 200 mg, orally (po), followed 24 h later by misoprostol 800 μg, vaginally (pv), for the treatment of EPF. Methods: We enrolled 30 women with EPF in this pilot clinical trial. All women used misoprostol 800 μg, pv, 24 h after ingesting 200 mg mifepristone. Follow-up evaluations with transvaginal ultrasonography occurred at 24 h and 1 week after treatment. Participants were offered a repeat dose of misoprostol if the pregnancy had not been expelled at the first follow-up. Results: The expulsion rate with one dose of misoprostol was 90% (95% CI=79-100%). The overall success rate of the treatment was 93% (95% CI=84-100%). Conclusion: This regimen of mifepristone followed by vaginal misoprostol appears to be an efficacious and acceptable treatment for EPF and may have improved results over a single dose of misoprostol alone.

Original languageEnglish (US)
Pages (from-to)458-462
Number of pages5
Issue number6
StatePublished - Dec 2006
Externally publishedYes


  • Early pregnancy failure
  • Mifepristone
  • Misoprostol
  • Spontaneous abortion

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology


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