Abstract
Hydantoin ring formation via carbanilide cyclization is achieved in high yield with short reaction time by employing catalytic amounts of Ba(OH)2 (anhydrous or octahydrate) in DMF under microwave irradiation. Evidence is provided that kinetic product 4 (trans, anti, cis stereochemistry) epimerizes to thermodynamic product 3 (trans, anti, trans stereochemistry).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3379-3382 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 39 |
| Issue number | 21 |
| DOIs | |
| State | Published - May 21 1998 |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Microwave-promoted reactions : Intramolecular carbanilide cyclization to hydantoins employing barium hydroxide catalyst. / Gong, Young Dae; Kurth, Mark J.
In: Tetrahedron Letters, Vol. 39, No. 21, 21.05.1998, p. 3379-3382.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microwave-promoted reactions
T2 - Intramolecular carbanilide cyclization to hydantoins employing barium hydroxide catalyst
AU - Gong, Young Dae
AU - Kurth, Mark J.
PY - 1998/5/21
Y1 - 1998/5/21
N2 - Hydantoin ring formation via carbanilide cyclization is achieved in high yield with short reaction time by employing catalytic amounts of Ba(OH)2 (anhydrous or octahydrate) in DMF under microwave irradiation. Evidence is provided that kinetic product 4 (trans, anti, cis stereochemistry) epimerizes to thermodynamic product 3 (trans, anti, trans stereochemistry).
AB - Hydantoin ring formation via carbanilide cyclization is achieved in high yield with short reaction time by employing catalytic amounts of Ba(OH)2 (anhydrous or octahydrate) in DMF under microwave irradiation. Evidence is provided that kinetic product 4 (trans, anti, cis stereochemistry) epimerizes to thermodynamic product 3 (trans, anti, trans stereochemistry).
UR - http://www.scopus.com/inward/record.url?scp=0032555024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032555024&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(98)00497-3
DO - 10.1016/S0040-4039(98)00497-3
M3 - Article
AN - SCOPUS:0032555024
VL - 39
SP - 3379
EP - 3382
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 21
ER -