Abstract
Hydantoin ring formation via carbanilide cyclization is achieved in high yield with short reaction time by employing catalytic amounts of Ba(OH)2 (anhydrous or octahydrate) in DMF under microwave irradiation. Evidence is provided that kinetic product 4 (trans, anti, cis stereochemistry) epimerizes to thermodynamic product 3 (trans, anti, trans stereochemistry).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3379-3382 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 39 |
| Issue number | 21 |
| DOIs | |
| State | Published - May 21 1998 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Cite this
Gong, Y. D., & Kurth, M. J. (1998). Microwave-promoted reactions: Intramolecular carbanilide cyclization to hydantoins employing barium hydroxide catalyst. Tetrahedron Letters, 39(21), 3379-3382. https://doi.org/10.1016/S0040-4039(98)00497-3