Microwave-promoted reactions: Intramolecular carbanilide cyclization to hydantoins employing barium hydroxide catalyst

Young Dae Gong, Mark J. Kurth

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Hydantoin ring formation via carbanilide cyclization is achieved in high yield with short reaction time by employing catalytic amounts of Ba(OH)2 (anhydrous or octahydrate) in DMF under microwave irradiation. Evidence is provided that kinetic product 4 (trans, anti, cis stereochemistry) epimerizes to thermodynamic product 3 (trans, anti, trans stereochemistry).

Original languageEnglish (US)
Pages (from-to)3379-3382
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number21
DOIs
StatePublished - May 21 1998

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Carbanilides
Hydantoins
Stereochemistry
Cyclization
Microwaves
Thermodynamics
Catalysts
Microwave irradiation
Kinetics
barium hydroxide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Microwave-promoted reactions : Intramolecular carbanilide cyclization to hydantoins employing barium hydroxide catalyst. / Gong, Young Dae; Kurth, Mark J.

In: Tetrahedron Letters, Vol. 39, No. 21, 21.05.1998, p. 3379-3382.

Research output: Contribution to journalArticle

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