Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H) -ones

Richard D. Carpenter, Kit Lam, Mark J. Kurth

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

An effective route to benzimidazo[2,1-b]quinazolin-12(5H)-ones from commercially available o-aryl isothiocyanate esters and o-phenylenediamines is reported. This method accommodates a variety of substituents on either starting material and proceeds under microwave irradiation in the presence of barium hydroxide, conditions that do not hydrolyze methyl ester substituents. The pharmacologically pertinent benzimidazoquinazolinone heterocycle is delivered in excellent yield and purity via both solution- and solid-phase protocols, the latter involving traceless release from the resin.

Original languageEnglish (US)
Pages (from-to)284-287
Number of pages4
JournalJournal of Organic Chemistry
Volume72
Issue number1
DOIs
StatePublished - Jan 5 2007

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H) -ones'. Together they form a unique fingerprint.

  • Cite this