Microwave Effects on Input Resistance and Action Potential Firing of Snail Neurons

Kenneth S Ginsburg, James C. Lin, William D. O’Neill

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Excitable tissues have been reported to respond to weak microwave (MW) fields, possibly by nonlinear perturbation of a cellular process such as ion conduction across membranes. We sought effects of MW (continuous wave, 2.45 GHz, specific absorption rates 12.5 or 125 mW/g) on input resistances and action potential (AP) intervals of neurons in ganglia of snails (Helix aspersa), at 20.9 ± 0.1°C. At 12.5 mW/g, input resistance did not change during irradiation, but increased (p < 0.05) afterward. At 125 mW/g, input resistance during irradiation was lower than in unirradiated controls. Serial cor-relograms changed marginally more frequently in MW experiments than in controls, but the changes had no consistent pattern. The AP firing rate was affected by MW, but the direction was not consistent across cells. When AP generation was modeled as being due to a neuronal input current, MW did not affect its mean, standard deviation, or autocorrelation. Unlike MW, temperature changes caused neurons to respond robustly and reversibly. Threshold for changing input resistance was 0.63°C. The data suggest that MW may enhance degenerative effects such as metabolic rundown or loss of ion channel patency, but do not indicate a specific mechanism for MW interaction with neurons.

Original languageEnglish (US)
Pages (from-to)1011-1021
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Volume39
Issue number10
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Neurons
Microwaves
Irradiation
Ions
Autocorrelation
Tissue
Membranes
Experiments

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Microwave Effects on Input Resistance and Action Potential Firing of Snail Neurons. / Ginsburg, Kenneth S; Lin, James C.; O’Neill, William D.

In: IEEE Transactions on Biomedical Engineering, Vol. 39, No. 10, 1992, p. 1011-1021.

Research output: Contribution to journalArticle

@article{782212343daa4aeb823444e355764282,
title = "Microwave Effects on Input Resistance and Action Potential Firing of Snail Neurons",
abstract = "Excitable tissues have been reported to respond to weak microwave (MW) fields, possibly by nonlinear perturbation of a cellular process such as ion conduction across membranes. We sought effects of MW (continuous wave, 2.45 GHz, specific absorption rates 12.5 or 125 mW/g) on input resistances and action potential (AP) intervals of neurons in ganglia of snails (Helix aspersa), at 20.9 ± 0.1°C. At 12.5 mW/g, input resistance did not change during irradiation, but increased (p < 0.05) afterward. At 125 mW/g, input resistance during irradiation was lower than in unirradiated controls. Serial cor-relograms changed marginally more frequently in MW experiments than in controls, but the changes had no consistent pattern. The AP firing rate was affected by MW, but the direction was not consistent across cells. When AP generation was modeled as being due to a neuronal input current, MW did not affect its mean, standard deviation, or autocorrelation. Unlike MW, temperature changes caused neurons to respond robustly and reversibly. Threshold for changing input resistance was 0.63°C. The data suggest that MW may enhance degenerative effects such as metabolic rundown or loss of ion channel patency, but do not indicate a specific mechanism for MW interaction with neurons.",
author = "Ginsburg, {Kenneth S} and Lin, {James C.} and O’Neill, {William D.}",
year = "1992",
doi = "10.1109/10.161333",
language = "English (US)",
volume = "39",
pages = "1011--1021",
journal = "IEEE Transactions on Biomedical Engineering",
issn = "0018-9294",
publisher = "IEEE Computer Society",
number = "10",

}

TY - JOUR

T1 - Microwave Effects on Input Resistance and Action Potential Firing of Snail Neurons

AU - Ginsburg, Kenneth S

AU - Lin, James C.

AU - O’Neill, William D.

PY - 1992

Y1 - 1992

N2 - Excitable tissues have been reported to respond to weak microwave (MW) fields, possibly by nonlinear perturbation of a cellular process such as ion conduction across membranes. We sought effects of MW (continuous wave, 2.45 GHz, specific absorption rates 12.5 or 125 mW/g) on input resistances and action potential (AP) intervals of neurons in ganglia of snails (Helix aspersa), at 20.9 ± 0.1°C. At 12.5 mW/g, input resistance did not change during irradiation, but increased (p < 0.05) afterward. At 125 mW/g, input resistance during irradiation was lower than in unirradiated controls. Serial cor-relograms changed marginally more frequently in MW experiments than in controls, but the changes had no consistent pattern. The AP firing rate was affected by MW, but the direction was not consistent across cells. When AP generation was modeled as being due to a neuronal input current, MW did not affect its mean, standard deviation, or autocorrelation. Unlike MW, temperature changes caused neurons to respond robustly and reversibly. Threshold for changing input resistance was 0.63°C. The data suggest that MW may enhance degenerative effects such as metabolic rundown or loss of ion channel patency, but do not indicate a specific mechanism for MW interaction with neurons.

AB - Excitable tissues have been reported to respond to weak microwave (MW) fields, possibly by nonlinear perturbation of a cellular process such as ion conduction across membranes. We sought effects of MW (continuous wave, 2.45 GHz, specific absorption rates 12.5 or 125 mW/g) on input resistances and action potential (AP) intervals of neurons in ganglia of snails (Helix aspersa), at 20.9 ± 0.1°C. At 12.5 mW/g, input resistance did not change during irradiation, but increased (p < 0.05) afterward. At 125 mW/g, input resistance during irradiation was lower than in unirradiated controls. Serial cor-relograms changed marginally more frequently in MW experiments than in controls, but the changes had no consistent pattern. The AP firing rate was affected by MW, but the direction was not consistent across cells. When AP generation was modeled as being due to a neuronal input current, MW did not affect its mean, standard deviation, or autocorrelation. Unlike MW, temperature changes caused neurons to respond robustly and reversibly. Threshold for changing input resistance was 0.63°C. The data suggest that MW may enhance degenerative effects such as metabolic rundown or loss of ion channel patency, but do not indicate a specific mechanism for MW interaction with neurons.

UR - http://www.scopus.com/inward/record.url?scp=0026931367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026931367&partnerID=8YFLogxK

U2 - 10.1109/10.161333

DO - 10.1109/10.161333

M3 - Article

C2 - 1280617

AN - SCOPUS:0026931367

VL - 39

SP - 1011

EP - 1021

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

SN - 0018-9294

IS - 10

ER -