Abstract
A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave (μW) assisted intramolecular arene-alkene coupling reaction. This report further demonstrates the versatility of this method by constructing 3-carboalkoxy-and 3-cyanoindoles. Optimization data, substrate scope, and applications are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 362-365 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 18 2013 |
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ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
Cite this
Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. / Nguyen, Huy H.; Kurth, Mark J.
In: Organic Letters, Vol. 15, No. 2, 18.01.2013, p. 362-365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling
AU - Nguyen, Huy H.
AU - Kurth, Mark J.
PY - 2013/1/18
Y1 - 2013/1/18
N2 - A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave (μW) assisted intramolecular arene-alkene coupling reaction. This report further demonstrates the versatility of this method by constructing 3-carboalkoxy-and 3-cyanoindoles. Optimization data, substrate scope, and applications are discussed.
AB - A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave (μW) assisted intramolecular arene-alkene coupling reaction. This report further demonstrates the versatility of this method by constructing 3-carboalkoxy-and 3-cyanoindoles. Optimization data, substrate scope, and applications are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=84872542469&partnerID=8YFLogxK
U2 - 10.1021/ol303314x
DO - 10.1021/ol303314x
M3 - Article
C2 - 23268775
AN - SCOPUS:84872542469
VL - 15
SP - 362
EP - 365
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 2
ER -