Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling

Huy H. Nguyen, Mark J. Kurth

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave (μW) assisted intramolecular arene-alkene coupling reaction. This report further demonstrates the versatility of this method by constructing 3-carboalkoxy-and 3-cyanoindoles. Optimization data, substrate scope, and applications are discussed.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalOrganic Letters
Volume15
Issue number2
DOIs
StatePublished - Jan 18 2013

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Regioselectivity
Alkenes
versatility
Microwaves
alkenes
microwaves
optimization
Substrates
synthesis
3-cyanoindole

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. / Nguyen, Huy H.; Kurth, Mark J.

In: Organic Letters, Vol. 15, No. 2, 18.01.2013, p. 362-365.

Research output: Contribution to journalArticle

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