Abstract
A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave (μW) assisted intramolecular arene-alkene coupling reaction. This report further demonstrates the versatility of this method by constructing 3-carboalkoxy-and 3-cyanoindoles. Optimization data, substrate scope, and applications are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 362-365 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 18 2013 |
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
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Nguyen, H. H., & Kurth, M. J. (2013). Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. Organic Letters, 15(2), 362-365. https://doi.org/10.1021/ol303314x