Abstract
A convenient solid phase synthesis of trisubstituted imidazolidinones and pyrimidinones via microwave assisted DIC-promoted intramolecular cyclization is described. Intramolecular cyclization of a resin-bound thiourea prepared by acylation of a dipeptide with an aryl isothiocyanate was rapidly promoted with DIC under microwave to afford imidazolidinones and tetrahydropyrimidinones in good yield and purity.
Original language | English (US) |
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Pages (from-to) | 5747-5750 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 34 |
DOIs | |
State | Published - Aug 22 2005 |
Keywords
- DIC-promoted
- Imidazolidinone
- Intramolecular cyclization
- Microwave
- Pyrimidinone
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery