Microvascular injury: Mechanisms and modulation

Fitz Roy E Curry

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A common end point of many signaling pathways to increase permeability in cultured endothelial cell monolayers is increased phosphorylation of myosin light chains, a step assumed to be necessary for activation of contractile mechanisms in endothelial cells. However, the signaling pathways which modulate permeability in cultured endothelial cells, differ significantly from those that regulate permeability in intact venular microvessels. One reason for this difference may be that endothelial cells in culture express a phenotype with exaggerated contractile machinery. If this phenotype arises as the result of the process of harvesting and culturing endothelial cells, it is possible that some endothelial cells in culture are more characteristic of microvessel endothelium that has been subjected to injury (e.g. from oxidant stress, leukocyte attachment, or repeated exposure to inflammatory conditions) than the endothelium of uninjured microvessels. It follows that agents that attenuate increased endothelial barrier permeability in cultured endothelial monolayers (e.g. regulators of the Rho-Rho kinase pathway, including the statins) may be useful candidates for the treatment of chronic dysfunction of the endothelial barrier.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalInternational Journal of Angiology
Volume11
Issue number1
DOIs
StatePublished - 2002

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Endothelial Cells
Permeability
Wounds and Injuries
Microvessels
Endothelium
Cultured Cells
Cell Culture Techniques
Phenotype
Hydroxymethylglutaryl-CoA Reductase Inhibitors
rho-Associated Kinases
Myosin Light Chains
Oxidants
Leukocytes
Phosphorylation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Microvascular injury : Mechanisms and modulation. / Curry, Fitz Roy E.

In: International Journal of Angiology, Vol. 11, No. 1, 2002, p. 1-6.

Research output: Contribution to journalArticle

Curry, Fitz Roy E. / Microvascular injury : Mechanisms and modulation. In: International Journal of Angiology. 2002 ; Vol. 11, No. 1. pp. 1-6.
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