Abstract
The frequency of triplet gestation is low in humans, estimated at 1:6400 deliveries. Monochorionic gestations represent a subpopulation of approximately 10% of these triplet pregnancies. Hypertensive complications are known to occur with greater frequency in the context of multiple gestation. In this report we describe microscopic placental changes associated with pre-eclampsia and proteinuria in the setting of an uncommon monochorionic-triamniotic triplet pregnancy achieved via in vitro fertilization. Histologic features observed in this case include placental stromal fibrosis and increased syncytial nodularity (Tenney-Parker change). In this triplet delivery resulting from two consecutive fissions of a single embryo, chorion and amnion configuration are also characterized with a review of the literature discussing the potential relationship between in vitro culture conditions and monozygotic multiple gestation.
Original language | English (US) |
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Pages (from-to) | 1241-1244 |
Number of pages | 4 |
Journal | Histology and Histopathology |
Volume | 19 |
Issue number | 4 |
State | Published - Oct 2004 |
Externally published | Yes |
Keywords
- Hypertension
- IVF
- Multiple gestation
- Prematurity
- Syncytial nodularity
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Histology
- Cell Biology