Abstract
The frequency of triplet gestation is low in humans, estimated at 1:6400 deliveries. Monochorionic gestations represent a subpopulation of approximately 10% of these triplet pregnancies. Hypertensive complications are known to occur with greater frequency in the context of multiple gestation. In this report we describe microscopic placental changes associated with pre-eclampsia and proteinuria in the setting of an uncommon monochorionic-triamniotic triplet pregnancy achieved via in vitro fertilization. Histologic features observed in this case include placental stromal fibrosis and increased syncytial nodularity (Tenney-Parker change). In this triplet delivery resulting from two consecutive fissions of a single embryo, chorion and amnion configuration are also characterized with a review of the literature discussing the potential relationship between in vitro culture conditions and monozygotic multiple gestation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1241-1244 |
| Number of pages | 4 |
| Journal | Histology and Histopathology |
| Volume | 19 |
| Issue number | 4 |
| State | Published - Oct 2004 |
| Externally published | Yes |
Fingerprint
Keywords
- Hypertension
- IVF
- Multiple gestation
- Prematurity
- Syncytial nodularity
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Histology
- Cell Biology
Cite this
Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization. / Sills, E. S.; Ghulmiyyah, L. M.; Wehbe, S. A.; Atkinson, P. F.; Perloe, M.; Tucker, M. J.
In: Histology and Histopathology, Vol. 19, No. 4, 10.2004, p. 1241-1244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization
AU - Sills, E. S.
AU - Ghulmiyyah, L. M.
AU - Wehbe, S. A.
AU - Atkinson, P. F.
AU - Perloe, M.
AU - Tucker, M. J.
PY - 2004/10
Y1 - 2004/10
N2 - The frequency of triplet gestation is low in humans, estimated at 1:6400 deliveries. Monochorionic gestations represent a subpopulation of approximately 10% of these triplet pregnancies. Hypertensive complications are known to occur with greater frequency in the context of multiple gestation. In this report we describe microscopic placental changes associated with pre-eclampsia and proteinuria in the setting of an uncommon monochorionic-triamniotic triplet pregnancy achieved via in vitro fertilization. Histologic features observed in this case include placental stromal fibrosis and increased syncytial nodularity (Tenney-Parker change). In this triplet delivery resulting from two consecutive fissions of a single embryo, chorion and amnion configuration are also characterized with a review of the literature discussing the potential relationship between in vitro culture conditions and monozygotic multiple gestation.
AB - The frequency of triplet gestation is low in humans, estimated at 1:6400 deliveries. Monochorionic gestations represent a subpopulation of approximately 10% of these triplet pregnancies. Hypertensive complications are known to occur with greater frequency in the context of multiple gestation. In this report we describe microscopic placental changes associated with pre-eclampsia and proteinuria in the setting of an uncommon monochorionic-triamniotic triplet pregnancy achieved via in vitro fertilization. Histologic features observed in this case include placental stromal fibrosis and increased syncytial nodularity (Tenney-Parker change). In this triplet delivery resulting from two consecutive fissions of a single embryo, chorion and amnion configuration are also characterized with a review of the literature discussing the potential relationship between in vitro culture conditions and monozygotic multiple gestation.
KW - Hypertension
KW - IVF
KW - Multiple gestation
KW - Prematurity
KW - Syncytial nodularity
UR - http://www.scopus.com/inward/record.url?scp=6344284697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=6344284697&partnerID=8YFLogxK
M3 - Article
C2 - 15375768
AN - SCOPUS:6344284697
VL - 19
SP - 1241
EP - 1244
JO - Histology and Histopathology
JF - Histology and Histopathology
SN - 0213-3911
IS - 4
ER -