Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization

E. S. Sills, L. M. Ghulmiyyah, S. A. Wehbe, P. F. Atkinson, M. Perloe, M. J. Tucker

Research output: Contribution to journalArticle

Abstract

The frequency of triplet gestation is low in humans, estimated at 1:6400 deliveries. Monochorionic gestations represent a subpopulation of approximately 10% of these triplet pregnancies. Hypertensive complications are known to occur with greater frequency in the context of multiple gestation. In this report we describe microscopic placental changes associated with pre-eclampsia and proteinuria in the setting of an uncommon monochorionic-triamniotic triplet pregnancy achieved via in vitro fertilization. Histologic features observed in this case include placental stromal fibrosis and increased syncytial nodularity (Tenney-Parker change). In this triplet delivery resulting from two consecutive fissions of a single embryo, chorion and amnion configuration are also characterized with a review of the literature discussing the potential relationship between in vitro culture conditions and monozygotic multiple gestation.

Original languageEnglish (US)
Pages (from-to)1241-1244
Number of pages4
JournalHistology and Histopathology
Volume19
Issue number4
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Fertilization in Vitro
Placenta
Histology
Triplet Pregnancy
Pregnancy
Membranes
Chorion
Amnion
Pre-Eclampsia
Proteinuria
Fibrosis
Embryonic Structures

Keywords

  • Hypertension
  • IVF
  • Multiple gestation
  • Prematurity
  • Syncytial nodularity

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Sills, E. S., Ghulmiyyah, L. M., Wehbe, S. A., Atkinson, P. F., Perloe, M., & Tucker, M. J. (2004). Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization. Histology and Histopathology, 19(4), 1241-1244.

Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization. / Sills, E. S.; Ghulmiyyah, L. M.; Wehbe, S. A.; Atkinson, P. F.; Perloe, M.; Tucker, M. J.

In: Histology and Histopathology, Vol. 19, No. 4, 10.2004, p. 1241-1244.

Research output: Contribution to journalArticle

Sills, ES, Ghulmiyyah, LM, Wehbe, SA, Atkinson, PF, Perloe, M & Tucker, MJ 2004, 'Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization', Histology and Histopathology, vol. 19, no. 4, pp. 1241-1244.
Sills, E. S. ; Ghulmiyyah, L. M. ; Wehbe, S. A. ; Atkinson, P. F. ; Perloe, M. ; Tucker, M. J. / Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization. In: Histology and Histopathology. 2004 ; Vol. 19, No. 4. pp. 1241-1244.
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