Microstimulation of macaque area LIP affects decision-making in a motion discrimination task

Timothy Hanks, Jochen Ditterich, Michael N. Shadlen

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

A central goal of cognitive neuroscience is to elucidate the neural mechanisms underlying decision-making. Recent physiological studies suggest that neurons in association areas may be involved in this process. To test this, we measured the effects of electrical microstimulation in the lateral intraparietal area (LIP) while monkeys performed a reaction-time motion discrimination task with a saccadic response. In each experiment, we identified a cluster of LIP cells with overlapping response fields (RFs) and sustained activity during memory-guided saccades. Microstimulation of this cluster caused an increase in the proportion of choices toward the RF of the stimulated neurons. Choices toward the stimulated RF were faster with microstimulation, while choices in the opposite direction were slower. Microstimulation never directly evoked saccades, nor did it change reaction times in a simple saccade task. These results demonstrate that the discharge of LIP neurons is causally related to decision formation in the discrimination task.

Original languageEnglish (US)
Pages (from-to)682-689
Number of pages8
JournalNature Neuroscience
Volume9
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

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Saccades
Macaca
Decision Making
Neurons
Reaction Time
Haplorhini
Discrimination (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Microstimulation of macaque area LIP affects decision-making in a motion discrimination task. / Hanks, Timothy; Ditterich, Jochen; Shadlen, Michael N.

In: Nature Neuroscience, Vol. 9, No. 5, 05.2006, p. 682-689.

Research output: Contribution to journalArticle

Hanks, Timothy ; Ditterich, Jochen ; Shadlen, Michael N. / Microstimulation of macaque area LIP affects decision-making in a motion discrimination task. In: Nature Neuroscience. 2006 ; Vol. 9, No. 5. pp. 682-689.
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