Microscopic modeling of NO and S-nitrosoglutathione kinetics and transport in human airways

Hye Won Shin, Steven George

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Nitric oxide (NO) appears in the exhaled breath and is elevated in inflammatory diseases. We developed a steady-state mathematical model of the bronchial mucosa for normal small and large airways to understand NO and S-nitrosoglutathione (GSNO) kinetics and transport using data from the existing literature. Our model predicts that mean steady-state NO and GSNO concentrations for large airways (generation 1) are 2.68 nM and 113 pM, respectively, in the epithelial cells and 0.11 nM (∼66 ppb) and 507 nM in the mucus. For small airways (generation 15), the mean concentrations of NO and GSNO, respectively, are 0.26 nM and 21 pM in the epithelial cells and 0.02 nM (∼12 ppb) and 132 nM in the mucus. The concentrations in the mucus compare favorably to experimentally measured values. We conclude that 1) the majority of free NO in the mucus, and thus exhaled NO, is due to diffusion of free NO from the epithelial cell and 2) the heterogeneous airway contribution to exhaled NO is due to heterogeneous airway geometries, such as epithelium and mucus thickness.

Original languageEnglish (US)
Pages (from-to)777-788
Number of pages12
JournalJournal of Applied Physiology
Volume90
Issue number3
StatePublished - Mar 6 2001

Keywords

  • Exhalation
  • Inflammation
  • Nitric oxide

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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