MicroRNAs in the development and progression of prostate cancer

Nagalakshmi Nadiminty, Ramakumar Tummala, Allen C Gao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Prostate cancer is one of the cancers with high incidence and mortality rates among US men. Even though prostate-specific antigen screening and other diagnostic approaches have improved patient prognosis, an urgent need for molecularly-based biomarkers of progression persists. MicroRNA (miRNA) dysregulation can have profound consequences as the loss of tumor-suppressive miRNAs enhances the expression of target oncogenes, while the upregulation of oncogenic miRNAs represses the target tumor suppressor genes. The realization of the importance of miRNAs in biological processes has led to a quest to understand the molecular mechanisms regulating miRNAs using a variety of model systems and to entertain the possibility of using miRNA antagonists or mimics for anticancer therapy. The promise of miRNAs as diagnostic and prognostic markers will also need to be realized by using validated datasets and standardized methodologies which will give us a way to compare and verify expression profiles. Here, we discuss the past and current studies which have led us to this point as miRNA-based therapeutics make their way into clinical trials.

Original languageEnglish (US)
Title of host publicationMicroRNA in Development and in the Progression of Cancer
PublisherSpringer New York
Pages265-286
Number of pages22
ISBN (Print)9781489980656, 1489980644, 9781489980649
DOIs
StatePublished - Jan 1 2014

Keywords

  • Androgen receptor
  • Biomarkers
  • Circulating miRNA
  • Clinical trials
  • CRPC
  • Epigenetics
  • MicroRNAs
  • p53
  • Progression
  • Prostate cancer

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Nadiminty, N., Tummala, R., & Gao, A. C. (2014). MicroRNAs in the development and progression of prostate cancer. In MicroRNA in Development and in the Progression of Cancer (pp. 265-286). Springer New York. https://doi.org/10.1007/978-1-4899-8065-6_14