MicroRNA-based therapeutics in central nervous system injuries

Ping Sun, Da Liu, Glen C. Jickling, Frank R Sharp, Ke Jie Yin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), are important causes of death and long-term disability worldwide. MicroRNA (miRNA), small non-coding RNA molecules that negatively regulate gene expression, can serve as diagnostic biomarkers and are emerging as novel therapeutic targets for CNS injuries. MiRNA-based therapeutics include miRNA mimics and inhibitors (antagomiRs) to respectively decrease and increase the expression of target genes. In this review, we summarize current miRNA-based therapeutic applications in stroke, TBI and SCI. Administration methods, time windows and dosage for effective delivery of miRNA-based drugs into CNS are discussed. The underlying mechanisms of miRNA-based therapeutics are reviewed including oxidative stress, inflammation, apoptosis, blood–brain barrier protection, angiogenesis and neurogenesis. Pharmacological agents that protect against CNS injuries by targeting specific miRNAs are presented along with the challenges and therapeutic potential of miRNA-based therapies.

Original languageEnglish (US)
JournalJournal of Cerebral Blood Flow and Metabolism
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Nervous System Trauma
MicroRNAs
Central Nervous System
Spinal Cord Injuries
Therapeutics
Stroke
Central Nervous System Agents
Gene Expression
Small Untranslated RNA
Neurogenesis
Cause of Death
Oxidative Stress
Biomarkers
Pharmacology
Apoptosis
Inflammation

Keywords

  • microRNA inhibitors
  • MicroRNA mimics
  • spinal cord injury
  • stroke
  • traumatic brain injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

MicroRNA-based therapeutics in central nervous system injuries. / Sun, Ping; Liu, Da; Jickling, Glen C.; Sharp, Frank R; Yin, Ke Jie.

In: Journal of Cerebral Blood Flow and Metabolism, 01.01.2018.

Research output: Contribution to journalArticle

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