MicroPET II

Design, development and initial performance of an improved microPET scanner for small-animal imaging

Yuan Chuan Tai, Arion F. Chatziioannou, Yongfeng Yang, Robert W. Silverman, Ken Meadors, Stefan Siegel, Danny F. Newport, Jennifer R. Stickel, Simon R Cherry

Research output: Contribution to journalArticle

227 Citations (Scopus)

Abstract

MicroPET II is a second-generation animal PET scanner designed for high-resolution imaging of small laboratory rodents. The system consists of 90 scintillation detector modules arranged in three contiguous axial rings with a ring diameter of 16.0 cm and an axial length of 4.9 cm. Each detector module consists of a 14 × 14 array of lutetium oxyorthosilicate (LSO) crystals coupled to a multi-channel photomultiplier tube (MC-PMT) through a coherent optical fibre bundle. Each LSO crystal element measures 0.975 mm × 0.975 mm in cross section by 12,5 mm in length. A barium sulphate reflector material was used between LSO elements leading to a detector pitch of 1.15 mm in both axial and transverse directions, Fused optical fibre bundles were made from 90 μm diameter glass fibres with a numerical aperture of 0.56. Interstitial extramural absorber was added between the fibres to reduce optical cross talk. A charge-division readout circuit was implemented on printed circuit boards to decode the 196 crystals in each array from the outputs of the 64 anode signals of the MC-PMT, Electronics from Concorde Microsystems Inc. (Knoxville, TN) were used for signal amplification, digitization, event qualification, coincidence processing and data capture. Coincidence data were passed to a host PC that recorded events in list mode. Following acquisition, data were sorted into sinograms and reconstructed using Fourier rebinning and filtered backprojection algorithms. Basic evaluation of the system has been completed. The absolute sensitivity of the microPET II scanner was 2.26% at the centre of the field of view (CFOV) for an energy window of keV and a timing window of 10 ns. The intrinsic spatial resolution of the detectors in the system averaged 1.21 mm full width at half maximum (FWHM) when measured with a 22Na point source 0.5 mm in diameter. Reconstructed image resolution ranged from 0.83 mm FWHM at the CFOV to 1.47 mm FWHM in the radial direction, 1.17 mm FWHM in the tangential direction and 1.42 mm FWHM in the axial direction at 1 cm offset from the CFOV. These values represent highly significant improvements over our earlier microPET scanner (approximately fourfold sensitivity increase and 25-35% improvement in linear spatial resolution under equivalent operating conditions) and are expected to be further improved when the system is fully optimized.

Original languageEnglish (US)
Pages (from-to)1519-1537
Number of pages19
JournalPhysics in Medicine and Biology
Volume48
Issue number11
DOIs
StatePublished - Jun 7 2003

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Full width at half maximum
scanners
animals
Animals
Optical Fibers
Imaging techniques
field of view
Photomultipliers
detectors
photomultiplier tubes
Detectors
Crystals
bundles
Barium Sulfate
Optical fibers
Data acquisition
modules
spatial resolution
optical fibers
Lutetium

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

MicroPET II : Design, development and initial performance of an improved microPET scanner for small-animal imaging. / Tai, Yuan Chuan; Chatziioannou, Arion F.; Yang, Yongfeng; Silverman, Robert W.; Meadors, Ken; Siegel, Stefan; Newport, Danny F.; Stickel, Jennifer R.; Cherry, Simon R.

In: Physics in Medicine and Biology, Vol. 48, No. 11, 07.06.2003, p. 1519-1537.

Research output: Contribution to journalArticle

Tai, YC, Chatziioannou, AF, Yang, Y, Silverman, RW, Meadors, K, Siegel, S, Newport, DF, Stickel, JR & Cherry, SR 2003, 'MicroPET II: Design, development and initial performance of an improved microPET scanner for small-animal imaging', Physics in Medicine and Biology, vol. 48, no. 11, pp. 1519-1537. https://doi.org/10.1088/0031-9155/48/11/303
Tai, Yuan Chuan ; Chatziioannou, Arion F. ; Yang, Yongfeng ; Silverman, Robert W. ; Meadors, Ken ; Siegel, Stefan ; Newport, Danny F. ; Stickel, Jennifer R. ; Cherry, Simon R. / MicroPET II : Design, development and initial performance of an improved microPET scanner for small-animal imaging. In: Physics in Medicine and Biology. 2003 ; Vol. 48, No. 11. pp. 1519-1537.
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