Microneedles and transdermal applications

Raja K Sivamani, Dorian Liepmann, Howard I. Maibach

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


With the limitations of oral drug delivery and the pain and needle phobias associated with traditional injections, drug delivery research has focused on the transdermal delivery route. A formidable barrier to transdermal drug delivery is the stratum corneum, the superficial layer of the skin. In the last 10 years, microneedles were proposed as a mechanical tool to pierce through the stratum corneum, in order to create drug delivery channels without stimulating underlying pain nerves. Since then, the field of microneedles has rapidly evolved to spawn a plethora of potential transdermal applications. In this review, the authors provide an overview of the progress in microneedle research and design, and the advancements that have been made in employing this technology for transdermal applications.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalExpert Opinion on Drug Delivery
Issue number1
StatePublished - Jan 2007


  • Gene therapy
  • Injection
  • Microneedles
  • Skin
  • Stratum corneum
  • Transdermal drug delivery
  • Vaccines

ASJC Scopus subject areas

  • Pharmaceutical Science


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