Microfluidic sample preparation for immunoassays

Steven Visuri, William Benett, Kerry Bettencourt, John T Chang, Karl Fisher, Julie Hamilton, Peter Krulevitch, Christina Park, Cheryl Stockton, Lisa Tarte, Amy Wang, Thomas Wilson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Researchers at Lawrence Livermore National Laboratory are developing means to collect and identify fluid-based biological pathogens in the forms of proteins, viruses, and bacteria. To support detection instruments, we are developing a flexible fluidic sample preparation unit. The overall goal of this Microfluidic Module is to input a fluid sample, containing background particulates and potentially target compounds, and deliver a processed sample for detection. We are developing techniques for sample purification, mixing, and filtration that would be useful to many applications including immunologic and nucleic acid assays. Many of these fluidic functions are accomplished with acoustic radiation pressure or dielectrophoresis. We are integrating these technologies into packaged systems with pumps and valves to control fluid flow through the fluidic circuit.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsC H Mastrangelo, H Becker
Pages83-89
Number of pages7
Volume4560
DOIs
StatePublished - 2001
Externally publishedYes
EventMicrofluidics and BioMEMS - San Francisco, CA, United States
Duration: Oct 22 2001Oct 24 2001

Other

OtherMicrofluidics and BioMEMS
CountryUnited States
CitySan Francisco, CA
Period10/22/0110/24/01

Keywords

  • Dielectrophoresis
  • MEMS
  • Microfluidics
  • Sample handling

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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  • Cite this

    Visuri, S., Benett, W., Bettencourt, K., Chang, J. T., Fisher, K., Hamilton, J., Krulevitch, P., Park, C., Stockton, C., Tarte, L., Wang, A., & Wilson, T. (2001). Microfluidic sample preparation for immunoassays. In C. H. Mastrangelo, & H. Becker (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4560, pp. 83-89) https://doi.org/10.1117/12.443043