Microfluidic device to culture 3D in vitro human capillary networks

Monica L. Moya, Luis F. Alonzo, Steven George

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Models that aim to recapitulate the dynamic in vivo features of the microcirculation are crucial for studying vascularization. Cells in vivo respond not only to biochemical cues (e.g., growth factor gradients) but also sense mechanical cues (e.g., interstitial flow, vessel perfusion). Integrating the response of cells, the stroma, and the circulation in a dynamic 3D setting will create an environment suitable for the exploration of many fundamental vascularization processes. Here in this chapter, we describe an in vivo-inspired microenvironment that is conducive to the development of perfused human capillaries.

Original languageEnglish (US)
Title of host publicationBiomimetics and Stem Cells
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages21-27
Number of pages7
ISBN (Print)9781493913312
DOIs
StatePublished - Jan 1 2014

Publication series

NameMethods in Molecular Biology
Volume1202
ISSN (Print)1064-3745

Keywords

  • Microenviroment
  • Microfluidic platform
  • Perfused capillary networks
  • Tissue engineering
  • Vasculogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Moya, M. L., Alonzo, L. F., & George, S. (2014). Microfluidic device to culture 3D in vitro human capillary networks. In Biomimetics and Stem Cells: Methods and Protocols (pp. 21-27). (Methods in Molecular Biology; Vol. 1202). Humana Press Inc.. https://doi.org/10.1007/7651-2013-36