Microfluidic Characterization of a Valved Glaucoma Drainage Device With Implications for Enhanced Therapeutic Efficacy

Tingrui Pan, Zhihua Li, J. David Brown, Babak Ziaie

Research output: Contribution to journalConference articlepeer-review

4 Scopus citations

Abstract

In this paper, we report on the microfluidic characterization of a valved glaucoma drainage device (the Ahmed™ Glaucoma Valve). Using a microfluidic test set-up, we have simulated the aqueous humor flow and post implantation fibrous tissue encapsulation of the external plate. We have shown that, contrary to the prevailing belief, the valve significantly contributes to the total pressure even after the fibrous capsule formation. This was demonstrated both by disabling the valve using sharp dissection, and by bypassing it using a polyimide microtube. ANSYS™ and Fluent™ simulations verified the pressure measurements following the microtube insertion. Further reduction of intraocular pressure after fibrous capsule formation could significantly reduce the potential for glaucoma progression.

Original languageEnglish (US)
Pages (from-to)3317-3320
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume4
StatePublished - Dec 1 2003
Externally publishedYes
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Keywords

  • Fibrous Capsule
  • Glaucoma
  • Microfluidic
  • Microvalve
  • Nanopore Membrane
  • Valved GDD

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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