Microfluidic cap-To-dispense (μCD): A universal microfluidic-robotic interface for automated pipette-free high-precision liquid handling

Jingjing Wang, Ka Deng, Chuqing Zhou, Zecong Fang, Conary Meyer, Kaustubh Umesh Anjali Deshpande, Zhihao Li, Xianqiang Mi, Qian Luo, Bruce D Hammock, Cheemeng Tan, Yan Chen, Tingrui Pan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Microfluidic devices have been increasingly used for low-volume liquid handling operations. However, laboratory automation of such delicate devices has lagged behind due to the lack of world-To-chip (macro-To-micro) interfaces. In this paper, we have presented the first pipette-free robotic-microfluidic interface using a microfluidic-embedded container cap, referred to as a microfluidic cap-To-dispense (μCD), to achieve a seamless integration of liquid handling and robotic automation without any traditional pipetting steps. The μCD liquid handling platform offers a generic and modular way to connect the robotic device to standard liquid containers. It utilizes the high accuracy and high flexibility of the robotic system to recognize, capture and position; and then using microfluidic adaptive printing it can achieve high-precision on-demand volume distribution. With its modular connectivity, nanoliter processability, high adaptability, and multitask capacity, μCD shows great potential as a generic robotic-microfluidic interface for complete pipette-free liquid handling automation.

Original languageEnglish (US)
Pages (from-to)3405-3415
Number of pages11
JournalLab on a Chip
Volume19
Issue number20
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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    Wang, J., Deng, K., Zhou, C., Fang, Z., Meyer, C., Deshpande, K. U. A., Li, Z., Mi, X., Luo, Q., Hammock, B. D., Tan, C., Chen, Y., & Pan, T. (2019). Microfluidic cap-To-dispense (μCD): A universal microfluidic-robotic interface for automated pipette-free high-precision liquid handling. Lab on a Chip, 19(20), 3405-3415. https://doi.org/10.1039/c9lc00622b