Microfluidic cap-To-dispense (μCD): A universal microfluidic-robotic interface for automated pipette-free high-precision liquid handling

Jingjing Wang, Ka Deng, Chuqing Zhou, Zecong Fang, Conary Meyer, Kaustubh Umesh Anjali Deshpande, Zhihao Li, Xianqiang Mi, Qian Luo, Bruce D. Hammock, Cheemeng Tan, Yan Chen, Tingrui Pan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Microfluidic devices have been increasingly used for low-volume liquid handling operations. However, laboratory automation of such delicate devices has lagged behind due to the lack of world-To-chip (macro-To-micro) interfaces. In this paper, we have presented the first pipette-free robotic-microfluidic interface using a microfluidic-embedded container cap, referred to as a microfluidic cap-To-dispense (μCD), to achieve a seamless integration of liquid handling and robotic automation without any traditional pipetting steps. The μCD liquid handling platform offers a generic and modular way to connect the robotic device to standard liquid containers. It utilizes the high accuracy and high flexibility of the robotic system to recognize, capture and position; and then using microfluidic adaptive printing it can achieve high-precision on-demand volume distribution. With its modular connectivity, nanoliter processability, high adaptability, and multitask capacity, μCD shows great potential as a generic robotic-microfluidic interface for complete pipette-free liquid handling automation.

Original languageEnglish (US)
Pages (from-to)3405-3415
Number of pages11
JournalLab on a Chip
Volume19
Issue number20
DOIs
StatePublished - Jan 1 2019

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ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Wang, J., Deng, K., Zhou, C., Fang, Z., Meyer, C., Deshpande, K. U. A., Li, Z., Mi, X., Luo, Q., Hammock, B. D., Tan, C., Chen, Y., & Pan, T. (2019). Microfluidic cap-To-dispense (μCD): A universal microfluidic-robotic interface for automated pipette-free high-precision liquid handling. Lab on a Chip, 19(20), 3405-3415. https://doi.org/10.1039/c9lc00622b