Microcirculation and metastasis in a new mouse mammary tumor model system

Anthony T W Cheung, Lawrence J T Young, Peter C Y Chen, Chien Y. Chao, Assane Ndoye, Peter A Barry, William J. Muller, Robert Cardiff

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Two new metastatic mouse mammary tumor transplant lines have been established in nude mice. The Met-1 line, with the polyoma virus middle T (PyV-MT) transgene, metastasized with 100% efficiency. The Db-7 line, expressing a PyV-MT transgene mutated at positions 315 and 322, metastasized with 8.8% efficiency. Histology and computer-assisted intravital microscopy demonstrated that internal microcirculation in Met-1 was more complex than Db-7; Met-1 exhibited higher microvessel density and tortuosity (P<0.0001). These indices of microvascular complexity correlated with the higher Met-1 metastatic rate (P<0.0001). These two transplantable lines will be useful for investigating the complex relationship between angiogenesis and metastasis.

Original languageEnglish (US)
Pages (from-to)69-77
Number of pages9
JournalInternational Journal of Oncology
Volume11
Issue number1
StatePublished - 1997

Keywords

  • Angiogenesis
  • Mammary tumors
  • Metastasis
  • Microcirculation
  • Microvessel density
  • Tortuosity index

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Cheung, A. T. W., Young, L. J. T., Chen, P. C. Y., Chao, C. Y., Ndoye, A., Barry, P. A., Muller, W. J., & Cardiff, R. (1997). Microcirculation and metastasis in a new mouse mammary tumor model system. International Journal of Oncology, 11(1), 69-77.