Microchimerism decades after transfusion among combat-injured US veterans from the Vietnam, Korean, and World War II conflicts

Garth H Utter, Tzong Hae Lee, Ryan M. Rivers, Lani Montalvo, Li Wen, Daniel M. Chafets, William F. Reed, Michael P. Busch

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

BACKGROUND: Blood transfusion after traumatic injury can result in microchimerism (MC) of donor white cells (WBCs) in the recipient as late as 2 to 3 years postinjury, the longest prospective follow-up to date. The purpose of this study was to determine how long transfusion-associated MC lasts after traumatic injury. STUDY DESIGN AND METHODS: A group of US combat veterans who received transfusions who responded to a recruitment notice was retrospectively evaluated. Their blood was sampled, and MC was assessed by quantitative allele-specific polymerase chain reaction detection of differences at the HLA-DR locus or a panel of insertion-deletion polymorphism loci. Results of veterans were compared to those from an age- and gender-matched blood donor control group, from whom WBCs were retrieved from leukoreduction filters. RESULTS: Among 163 combat veterans who received transfusion and 150 control subjects who did not receive transfusions, 16 (9.8%) of the veterans and 1 (0.7%) control subject had evidence of MC (relative risk, 14.7; 95% confidence interval, 2.0-110). The veterans with MC included 3 who served in WWII (7% of subjects from that conflict), 5 in Korea (18%), and 6 in Vietnam (7%). CONCLUSIONS: Transfusion for combat-related injury can result in MC that lasts for 60 years, suggesting that it may involve permanent engraftment. MC is rare among male blood donors who did not receive transfusions, who are probably representative of individuals who have not had postnatal allogeneic exposures.

Original languageEnglish (US)
Pages (from-to)1609-1615
Number of pages7
JournalTransfusion
Volume48
Issue number8
DOIs
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Hematology
  • Immunology

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