Microbubble tunneling in gel phantoms

Charles F. Caskey, Shengping Qin, Paul A. Dayton, Katherine W. Ferrara

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Insonified microbubbles were observed in vessels within a gel with a Young's modulus similar to that of tissue, demonstrating shape instabilities, liquid jets, and the formation of small tunnels. In this study, tunnel formulation occurred in the direction of the propagating ultrasound wave, where radiation pressure directed the contact of the bubble and gel, facilitating the activity of the liquid jets. Combinations of ultrasonic parameters and microbubble concentrations that are relevant for diagnostic imaging and drug delivery and that lead to tunnel formation were applied and the resulting tunnel formation was quantified.

Original languageEnglish (US)
JournalJournal of the Acoustical Society of America
Volume125
Issue number5
DOIs
StatePublished - 2009

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tunnels
gels
radiation pressure
liquids
vessels
delivery
modulus of elasticity
electromagnetic radiation
drugs
bubbles
ultrasonics
formulations
Jets
Liquid
Imaging
Ultrasound
Diagnostics
Radiation
Waves
Drugs

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Caskey, C. F., Qin, S., Dayton, P. A., & Ferrara, K. W. (2009). Microbubble tunneling in gel phantoms. Journal of the Acoustical Society of America, 125(5). https://doi.org/10.1121/1.3097679

Microbubble tunneling in gel phantoms. / Caskey, Charles F.; Qin, Shengping; Dayton, Paul A.; Ferrara, Katherine W.

In: Journal of the Acoustical Society of America, Vol. 125, No. 5, 2009.

Research output: Contribution to journalArticle

Caskey, Charles F. ; Qin, Shengping ; Dayton, Paul A. ; Ferrara, Katherine W. / Microbubble tunneling in gel phantoms. In: Journal of the Acoustical Society of America. 2009 ; Vol. 125, No. 5.
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