Microbubble tunneling in gel phantoms

Charles F. Caskey, Shengping Qin, Paul A. Dayton, Katherine W. Ferrara

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Insonified microbubbles were observed in vessels within a gel with a Young's modulus similar to that of tissue, demonstrating shape instabilities, liquid jets, and the formation of small tunnels. In this study, tunnel formulation occurred in the direction of the propagating ultrasound wave, where radiation pressure directed the contact of the bubble and gel, facilitating the activity of the liquid jets. Combinations of ultrasonic parameters and microbubble concentrations that are relevant for diagnostic imaging and drug delivery and that lead to tunnel formation were applied and the resulting tunnel formation was quantified.

Original languageEnglish (US)
JournalJournal of the Acoustical Society of America
Issue number5
StatePublished - 2009

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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