Microbubble oscillation in tubes with diameters of 12, 25, and 195 microns

Charles F. Caskey; Dustin E. Kruse; Paul A. Dayton; Tyler K. Kitano; Katherine W. Ferrara

doi:10.1063/1.2164392

Microbubble oscillation in tubes with diameters of 12, 25, and 195 microns

Charles F. Caskey, Dustin E. Kruse, Paul A. Dayton, Tyler K. Kitano, Katherine W. Ferrara

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Ultrasound contrast agents are often used to measure flow rate in the microvasculature; however, the oscillation of these agents in capillary-sized tubes has not been directly observed. Here, oscillations of microbubbles are examined in microvessel phantoms with diameters similar to those of capillaries. High-speed camera images demonstrate the effects of ultrasonic pressure and tube diameter and length on microbubble expansion and fragmentation occurrence. Microbubble displacement due to radiation force is also demonstrated in a phantom microvessel.

Original language	English (US)
Article number	033902
Pages (from-to)	1-3
Number of pages	3
Journal	Applied Physics Letters
Volume	88
Issue number	3
DOIs	https://doi.org/10.1063/1.2164392
State	Published - 2006

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2164392

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abstract = "Ultrasound contrast agents are often used to measure flow rate in the microvasculature; however, the oscillation of these agents in capillary-sized tubes has not been directly observed. Here, oscillations of microbubbles are examined in microvessel phantoms with diameters similar to those of capillaries. High-speed camera images demonstrate the effects of ultrasonic pressure and tube diameter and length on microbubble expansion and fragmentation occurrence. Microbubble displacement due to radiation force is also demonstrated in a phantom microvessel.",

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AU - Caskey, Charles F.

AU - Kruse, Dustin E.

AU - Dayton, Paul A.

AU - Kitano, Tyler K.

AU - Ferrara, Katherine W.

PY - 2006

Y1 - 2006

N2 - Ultrasound contrast agents are often used to measure flow rate in the microvasculature; however, the oscillation of these agents in capillary-sized tubes has not been directly observed. Here, oscillations of microbubbles are examined in microvessel phantoms with diameters similar to those of capillaries. High-speed camera images demonstrate the effects of ultrasonic pressure and tube diameter and length on microbubble expansion and fragmentation occurrence. Microbubble displacement due to radiation force is also demonstrated in a phantom microvessel.

AB - Ultrasound contrast agents are often used to measure flow rate in the microvasculature; however, the oscillation of these agents in capillary-sized tubes has not been directly observed. Here, oscillations of microbubbles are examined in microvessel phantoms with diameters similar to those of capillaries. High-speed camera images demonstrate the effects of ultrasonic pressure and tube diameter and length on microbubble expansion and fragmentation occurrence. Microbubble displacement due to radiation force is also demonstrated in a phantom microvessel.

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Microbubble oscillation in tubes with diameters of 12, 25, and 195 microns

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