Abstract
This work describes the synthesis of (R)-Nifenalol® based on an enantioconvergent chemoenzymatic hydrolysis of para-nitrostyrene oxide. A mathematical approach is devised which allowed to optimize the process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9707-9714 |
| Number of pages | 8 |
| Journal | Tetrahedron |
| Volume | 53 |
| Issue number | 28 |
| DOIs | |
| State | Published - Jul 14 1997 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Pedragosa-Moreau, S., Morisseau, C., Baratti, J., Zylber, J., Archelas, A., & Furstoss, R. (1997). Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol® using a combined chemoenzymatic approach. Tetrahedron, 53(28), 9707-9714. https://doi.org/10.1016/S0040-4020(97)00639-X