Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol® using a combined chemoenzymatic approach

S. Pedragosa-Moreau; C. Morisseau; J. Baratti; J. Zylber; A. Archelas; R. Furstoss

doi:10.1016/S0040-4020(97)00639-X

Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol® using a combined chemoenzymatic approach

S. Pedragosa-Moreau, C. Morisseau, J. Baratti, J. Zylber, A. Archelas, R. Furstoss

Research output: Contribution to journal › Article

89 Scopus citations

Abstract

This work describes the synthesis of (R)-Nifenalol® based on an enantioconvergent chemoenzymatic hydrolysis of para-nitrostyrene oxide. A mathematical approach is devised which allowed to optimize the process.

Original language	English (US)
Pages (from-to)	9707-9714
Number of pages	8
Journal	Tetrahedron
Volume	53
Issue number	28
DOIs	https://doi.org/10.1016/S0040-4020(97)00639-X
State	Published - Jul 14 1997
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

Cite this

Pedragosa-Moreau, S., Morisseau, C., Baratti, J., Zylber, J., Archelas, A., & Furstoss, R. (1997). Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol® using a combined chemoenzymatic approach. Tetrahedron, 53(28), 9707-9714. https://doi.org/10.1016/S0040-4020(97)00639-X

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AU - Archelas, A.

AU - Furstoss, R.

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Access to Document

10.1016/S0040-4020(97)00639-X