Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol® using a combined chemoenzymatic approach

S. Pedragosa-Moreau, C. Morisseau, J. Baratti, J. Zylber, A. Archelas, R. Furstoss

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

This work describes the synthesis of (R)-Nifenalol® based on an enantioconvergent chemoenzymatic hydrolysis of para-nitrostyrene oxide. A mathematical approach is devised which allowed to optimize the process.

Original languageEnglish (US)
Pages (from-to)9707-9714
Number of pages8
JournalTetrahedron
Volume53
Issue number28
DOIs
StatePublished - Jul 14 1997
Externally publishedYes

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Hydrolysis
nifenalol
4-nitrostyrene oxide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol® using a combined chemoenzymatic approach. / Pedragosa-Moreau, S.; Morisseau, C.; Baratti, J.; Zylber, J.; Archelas, A.; Furstoss, R.

In: Tetrahedron, Vol. 53, No. 28, 14.07.1997, p. 9707-9714.

Research output: Contribution to journalArticle

Pedragosa-Moreau, S. ; Morisseau, C. ; Baratti, J. ; Zylber, J. ; Archelas, A. ; Furstoss, R. / Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol® using a combined chemoenzymatic approach. In: Tetrahedron. 1997 ; Vol. 53, No. 28. pp. 9707-9714.
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