Microbiological transformations 37. An enantioconvergent synthesis of the β-blocker (R)-Nifenalol® using a combined chemoenzymatic approach

S. Pedragosa-Moreau, C. Morisseau, J. Baratti, J. Zylber, A. Archelas, R. Furstoss

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

This work describes the synthesis of (R)-Nifenalol® based on an enantioconvergent chemoenzymatic hydrolysis of para-nitrostyrene oxide. A mathematical approach is devised which allowed to optimize the process.

Original languageEnglish (US)
Pages (from-to)9707-9714
Number of pages8
JournalTetrahedron
Volume53
Issue number28
DOIs
StatePublished - Jul 14 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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