Microbial genome sequencing 2000: New insights into physiology, evolution and expression analysis

William Nierman, Jonathan A Eisen, Claire M. Fraser

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The complete genome sequence has been reported for 24 microbial organisms. The genome organization and gene content of these organisms has revealed an incredible diversity. Nearly half of the open reading frames identified by these sequencing projects are for potential genes with no known biological function. Efforts to make evolutionary sense and biological sense of the gene content of these organisms have been initiated. The greatest future challenge of genomics will be to determine function for the unknown genes. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalResearch in Microbiology
Volume151
Issue number2
DOIs
StatePublished - Mar 2000
Externally publishedYes

Keywords

  • DNA
  • Expression regulation
  • Gene
  • Phylogeny
  • Sequence analysis

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology

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