Micorfluidic-based 3D microtissue with perfused human capillaries

Yu Hsiang Hsu, Monica Moya, Christopher C.W. Hughes, Steven George, Abraham P. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper reports, for the first time, a microfluidic model system that provides a three-dimensional biologically and anatomically correct environment for growing a human microtissue with perfused human capillaries in vitro. By mimicking ischemic environments in adult tissue, both vasculogenesis and angiogenesis approaches were applied to generate perfused capillary bed. Two microfluidic platforms embedded with a millimeter-sized micro-chamber connected to two side channels through multiple pores were designed. Preliminary results of vasculogenesis model show evidence of perfused capillaries in developed microtissues. Early stage of angiogenesis process was also observed in angiogenesis model.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1322-1324
Number of pages3
Volume2
StatePublished - Dec 1 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

Keywords

  • Angiogenesis
  • Microtissue
  • Perfused Capillaries
  • Vasculogenesis

ASJC Scopus subject areas

  • Control and Systems Engineering

Fingerprint Dive into the research topics of 'Micorfluidic-based 3D microtissue with perfused human capillaries'. Together they form a unique fingerprint.

  • Cite this

    Hsu, Y. H., Moya, M., Hughes, C. C. W., George, S., & Lee, A. P. (2010). Micorfluidic-based 3D microtissue with perfused human capillaries. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 2, pp. 1322-1324)