Michaelis-Menten mechanism reconsidered: implications of fractal kinetics

Michael A. Savageau

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

The Michaelis-Menten formalism assumes that the elementary steps of an enzymatic mechanism follow traditional mass-action kinetics. Recent evidence has shown that elementary bimolecular reactions under dimensionally-restricted conditions, such as those that might occurin vivowhen reactions are confined to two-dimensional membranes and one-dimensional channels, do not follow traditional mass-action kinetics, but fractal kinetics. A Michaelis-Menten-like reaction operating under conditions of dimensional restriction is shown to exhibit new types of synergism and noninteger kinetic orders. These properties are likely to have an important influence on the behavior of intact biochemical systems, which is largely dependent upon the kinetic orders of the constituent biochemical reactions.

Original languageEnglish (US)
Pages (from-to)115-124
Number of pages10
JournalJournal of Theoretical Biology
Volume176
Issue number1
DOIs
StatePublished - Sep 7 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Statistics and Probability
  • Modeling and Simulation
  • Applied Mathematics
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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