Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid

Asma Lat, George Richard Thompson, Michael G. Rinaldi, Sheryl A. Dorsey, Gennethel Pennick, James S. Lewis

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.

Original languageEnglish (US)
Pages (from-to)943-944
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number2
DOIs
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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