Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid

Asma Lat, George Richard Thompson, Michael G. Rinaldi, Sheryl A. Dorsey, Gennethel Pennick, James S. Lewis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.

Original languageEnglish (US)
Pages (from-to)943-944
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Pancreatic Pseudocyst
Brain
Central Nervous System
Invasive Candidiasis
Nerve Tissue
Complementary Therapies
Pharmacokinetics
Infection
micafungin
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid. / Lat, Asma; Thompson, George Richard; Rinaldi, Michael G.; Dorsey, Sheryl A.; Pennick, Gennethel; Lewis, James S.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 2, 02.2010, p. 943-944.

Research output: Contribution to journalArticle

Lat, Asma ; Thompson, George Richard ; Rinaldi, Michael G. ; Dorsey, Sheryl A. ; Pennick, Gennethel ; Lewis, James S. / Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid. In: Antimicrobial Agents and Chemotherapy. 2010 ; Vol. 54, No. 2. pp. 943-944.
@article{d7dcfcd1b1524a12b1cac2b91da08de1,
title = "Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid",
abstract = "We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.",
author = "Asma Lat and Thompson, {George Richard} and Rinaldi, {Michael G.} and Dorsey, {Sheryl A.} and Gennethel Pennick and Lewis, {James S.}",
year = "2010",
month = "2",
doi = "10.1128/AAC.01294-09",
language = "English (US)",
volume = "54",
pages = "943--944",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid

AU - Lat, Asma

AU - Thompson, George Richard

AU - Rinaldi, Michael G.

AU - Dorsey, Sheryl A.

AU - Pennick, Gennethel

AU - Lewis, James S.

PY - 2010/2

Y1 - 2010/2

N2 - We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.

AB - We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.

UR - http://www.scopus.com/inward/record.url?scp=75749106998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749106998&partnerID=8YFLogxK

U2 - 10.1128/AAC.01294-09

DO - 10.1128/AAC.01294-09

M3 - Article

VL - 54

SP - 943

EP - 944

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 2

ER -