MHC-guided processing: Binding of large antigen fragments

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Ever since the emergence of models for the processing and presentation of antigenic determinants by MHC class II molecules, the main view has been that proteins are unfolded, enzymatically cleaved into peptide lengths of about 12-25 amino acids and then loaded onto MHC class II molecules. There is, however, an alternative model stating that partially intact unfolding antigens are first bound by MHC class II molecules and then trimmed to fragments of a smaller size while remaining bound to the MHC class II molecule. In this analysis, we make the case that a considerable portion of the elutable peptide cargo belongs to this latter class.

Original languageEnglish (US)
Pages (from-to)621-629
Number of pages9
JournalNature Reviews Immunology
Issue number8
StatePublished - Aug 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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