TY - JOUR
T1 - MHC-guided processing
T2 - Binding of large antigen fragments
AU - Sercarz, Eli E.
AU - Maverakis, Emanual Michael
PY - 2003/8
Y1 - 2003/8
N2 - Ever since the emergence of models for the processing and presentation of antigenic determinants by MHC class II molecules, the main view has been that proteins are unfolded, enzymatically cleaved into peptide lengths of about 12-25 amino acids and then loaded onto MHC class II molecules. There is, however, an alternative model stating that partially intact unfolding antigens are first bound by MHC class II molecules and then trimmed to fragments of a smaller size while remaining bound to the MHC class II molecule. In this analysis, we make the case that a considerable portion of the elutable peptide cargo belongs to this latter class.
AB - Ever since the emergence of models for the processing and presentation of antigenic determinants by MHC class II molecules, the main view has been that proteins are unfolded, enzymatically cleaved into peptide lengths of about 12-25 amino acids and then loaded onto MHC class II molecules. There is, however, an alternative model stating that partially intact unfolding antigens are first bound by MHC class II molecules and then trimmed to fragments of a smaller size while remaining bound to the MHC class II molecule. In this analysis, we make the case that a considerable portion of the elutable peptide cargo belongs to this latter class.
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M3 - Article
C2 - 12974477
AN - SCOPUS:0141832121
VL - 3
SP - 621
EP - 629
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
SN - 1474-1733
IS - 8
ER -