MHC associations with clinical and autoantibody manifestations in European SLE

D. L. Morris, M. M A Fernando, K. E. Taylor, S. A. Chung, J. Nititham, M. E. Alarcón-Riquelme, L. F. Barcellos, T. W. Behrens, C. Cotsapas, P. M. Gaffney, R. R. Graham, B. A. Pons-Estel, P. K. Gregersen, J. B. Harley, S. L. Hauser, G. Hom, C. D. Langefeld, J. A. Noble, J. D. Rioux, Michael F SeldinT. J. Vyse, L. A. Criswell

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Abstract

Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to nuclear components. Although genetic variation within the major histocompatibility complex (MHC) is associated with SLE, its role in the development of clinical manifestations and autoantibody production is not well defined. We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. Of the 11 American College of Rheumatology criteria and 7 autoantibody sub-phenotypes examined, anti-Ro/SSA and anti-La/SSB antibody subsets exhibited the highest number and most statistically significant associations. HLA-DRB1*03:01 was significantly associated with both sub-phenotypes. We found evidence of associations independent of MHC class II variants in the anti-Ro subset alone. Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies.

Original languageEnglish (US)
Pages (from-to)210-217
Number of pages8
JournalGenes and Immunity
Volume15
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Major Histocompatibility Complex
Systemic Lupus Erythematosus
Autoantibodies
HLA Antigens
Phenotype
Alleles
Single Nucleotide Polymorphism
Meta-Analysis
Anti-Idiotypic Antibodies
Genotype
Amino Acids
Antibodies

Keywords

  • Europeans
  • Genetics
  • Meta-analysis
  • MHC
  • Sub-phenotype analysis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics
  • Medicine(all)

Cite this

Morris, D. L., Fernando, M. M. A., Taylor, K. E., Chung, S. A., Nititham, J., Alarcón-Riquelme, M. E., ... Criswell, L. A. (2014). MHC associations with clinical and autoantibody manifestations in European SLE. Genes and Immunity, 15(4), 210-217. https://doi.org/10.1038/gene.2014.6

MHC associations with clinical and autoantibody manifestations in European SLE. / Morris, D. L.; Fernando, M. M A; Taylor, K. E.; Chung, S. A.; Nititham, J.; Alarcón-Riquelme, M. E.; Barcellos, L. F.; Behrens, T. W.; Cotsapas, C.; Gaffney, P. M.; Graham, R. R.; Pons-Estel, B. A.; Gregersen, P. K.; Harley, J. B.; Hauser, S. L.; Hom, G.; Langefeld, C. D.; Noble, J. A.; Rioux, J. D.; Seldin, Michael F; Vyse, T. J.; Criswell, L. A.

In: Genes and Immunity, Vol. 15, No. 4, 2014, p. 210-217.

Research output: Contribution to journalArticle

Morris, DL, Fernando, MMA, Taylor, KE, Chung, SA, Nititham, J, Alarcón-Riquelme, ME, Barcellos, LF, Behrens, TW, Cotsapas, C, Gaffney, PM, Graham, RR, Pons-Estel, BA, Gregersen, PK, Harley, JB, Hauser, SL, Hom, G, Langefeld, CD, Noble, JA, Rioux, JD, Seldin, MF, Vyse, TJ & Criswell, LA 2014, 'MHC associations with clinical and autoantibody manifestations in European SLE', Genes and Immunity, vol. 15, no. 4, pp. 210-217. https://doi.org/10.1038/gene.2014.6
Morris DL, Fernando MMA, Taylor KE, Chung SA, Nititham J, Alarcón-Riquelme ME et al. MHC associations with clinical and autoantibody manifestations in European SLE. Genes and Immunity. 2014;15(4):210-217. https://doi.org/10.1038/gene.2014.6
Morris, D. L. ; Fernando, M. M A ; Taylor, K. E. ; Chung, S. A. ; Nititham, J. ; Alarcón-Riquelme, M. E. ; Barcellos, L. F. ; Behrens, T. W. ; Cotsapas, C. ; Gaffney, P. M. ; Graham, R. R. ; Pons-Estel, B. A. ; Gregersen, P. K. ; Harley, J. B. ; Hauser, S. L. ; Hom, G. ; Langefeld, C. D. ; Noble, J. A. ; Rioux, J. D. ; Seldin, Michael F ; Vyse, T. J. ; Criswell, L. A. / MHC associations with clinical and autoantibody manifestations in European SLE. In: Genes and Immunity. 2014 ; Vol. 15, No. 4. pp. 210-217.
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T1 - MHC associations with clinical and autoantibody manifestations in European SLE

AU - Morris, D. L.

AU - Fernando, M. M A

AU - Taylor, K. E.

AU - Chung, S. A.

AU - Nititham, J.

AU - Alarcón-Riquelme, M. E.

AU - Barcellos, L. F.

AU - Behrens, T. W.

AU - Cotsapas, C.

AU - Gaffney, P. M.

AU - Graham, R. R.

AU - Pons-Estel, B. A.

AU - Gregersen, P. K.

AU - Harley, J. B.

AU - Hauser, S. L.

AU - Hom, G.

AU - Langefeld, C. D.

AU - Noble, J. A.

AU - Rioux, J. D.

AU - Seldin, Michael F

AU - Vyse, T. J.

AU - Criswell, L. A.

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N2 - Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to nuclear components. Although genetic variation within the major histocompatibility complex (MHC) is associated with SLE, its role in the development of clinical manifestations and autoantibody production is not well defined. We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. Of the 11 American College of Rheumatology criteria and 7 autoantibody sub-phenotypes examined, anti-Ro/SSA and anti-La/SSB antibody subsets exhibited the highest number and most statistically significant associations. HLA-DRB1*03:01 was significantly associated with both sub-phenotypes. We found evidence of associations independent of MHC class II variants in the anti-Ro subset alone. Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies.

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