Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus

Sharon Adler, Madeleine Pahl, Hanna Abboud, Susanne Nicholas, Eli Ipp, Michael F Seldin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Diabetic nephropathy is a classic complex trait, whose development in a given individual reflects contributions from multiple genes and whose expression is modulated by environmental factors. Numerous genetic strategies have been used to identify common disease risk loci and genes, including candidate gene analyses, linkage analysis, transmission disequilibrium testing (a family based association test to identify linkage between a genetic marker and a biological trait or disease), and admixture mapping (also referred to as mapping by admixture linkage disequilibrium). Choosing the best genetic strategy to identify susceptibility genes in a disease is dependent on knowing whether the disorder is monogenic (the result of one gene), oligogenic (the result of a few genes), or polygenic (the result of many genes). The likelihood of finding risk loci for a disease with a putative genetic contribution is in part owing to the disease recurrence risk ratio (the risk of expressing the disease phenotype in siblings of the proband divided by the risk observed in the general population), the genotypic risk ratio (the risk of expressing the phenotype if the gene is present divided by the risk if the gene is not present), the number of susceptibility genes, how the susceptibility genes interact, how much of the disease risk is contributed by environmental factors, and the disease penetrance (the likelihood that the phenotype will be expressed if the gene is present).

Original languageEnglish (US)
Pages (from-to)141-149
Number of pages9
JournalSeminars in Nephrology
Volume30
Issue number2
DOIs
StatePublished - Mar 2010

Fingerprint

Diabetic Nephropathies
Type 2 Diabetes Mellitus
Genes
Phenotype
Odds Ratio
Penetrance
Linkage Disequilibrium
Genetic Association Studies
Genetic Markers
Siblings
Gene Expression
Recurrence

Keywords

  • Admixture mapping
  • Diabetic nephropathy risk loci
  • Mexican-Americans

ASJC Scopus subject areas

  • Nephrology

Cite this

Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus. / Adler, Sharon; Pahl, Madeleine; Abboud, Hanna; Nicholas, Susanne; Ipp, Eli; Seldin, Michael F.

In: Seminars in Nephrology, Vol. 30, No. 2, 03.2010, p. 141-149.

Research output: Contribution to journalArticle

Adler, Sharon ; Pahl, Madeleine ; Abboud, Hanna ; Nicholas, Susanne ; Ipp, Eli ; Seldin, Michael F. / Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus. In: Seminars in Nephrology. 2010 ; Vol. 30, No. 2. pp. 141-149.
@article{2a2850d7e8384bcea58aa5e343b30b11,
title = "Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus",
abstract = "Diabetic nephropathy is a classic complex trait, whose development in a given individual reflects contributions from multiple genes and whose expression is modulated by environmental factors. Numerous genetic strategies have been used to identify common disease risk loci and genes, including candidate gene analyses, linkage analysis, transmission disequilibrium testing (a family based association test to identify linkage between a genetic marker and a biological trait or disease), and admixture mapping (also referred to as mapping by admixture linkage disequilibrium). Choosing the best genetic strategy to identify susceptibility genes in a disease is dependent on knowing whether the disorder is monogenic (the result of one gene), oligogenic (the result of a few genes), or polygenic (the result of many genes). The likelihood of finding risk loci for a disease with a putative genetic contribution is in part owing to the disease recurrence risk ratio (the risk of expressing the disease phenotype in siblings of the proband divided by the risk observed in the general population), the genotypic risk ratio (the risk of expressing the phenotype if the gene is present divided by the risk if the gene is not present), the number of susceptibility genes, how the susceptibility genes interact, how much of the disease risk is contributed by environmental factors, and the disease penetrance (the likelihood that the phenotype will be expressed if the gene is present).",
keywords = "Admixture mapping, Diabetic nephropathy risk loci, Mexican-Americans",
author = "Sharon Adler and Madeleine Pahl and Hanna Abboud and Susanne Nicholas and Eli Ipp and Seldin, {Michael F}",
year = "2010",
month = "3",
doi = "10.1016/j.semnephrol.2010.01.005",
language = "English (US)",
volume = "30",
pages = "141--149",
journal = "Seminars in Nephrology",
issn = "0270-9295",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Mexican-American admixture mapping analyses for diabetic nephropathy in type 2 diabetes mellitus

AU - Adler, Sharon

AU - Pahl, Madeleine

AU - Abboud, Hanna

AU - Nicholas, Susanne

AU - Ipp, Eli

AU - Seldin, Michael F

PY - 2010/3

Y1 - 2010/3

N2 - Diabetic nephropathy is a classic complex trait, whose development in a given individual reflects contributions from multiple genes and whose expression is modulated by environmental factors. Numerous genetic strategies have been used to identify common disease risk loci and genes, including candidate gene analyses, linkage analysis, transmission disequilibrium testing (a family based association test to identify linkage between a genetic marker and a biological trait or disease), and admixture mapping (also referred to as mapping by admixture linkage disequilibrium). Choosing the best genetic strategy to identify susceptibility genes in a disease is dependent on knowing whether the disorder is monogenic (the result of one gene), oligogenic (the result of a few genes), or polygenic (the result of many genes). The likelihood of finding risk loci for a disease with a putative genetic contribution is in part owing to the disease recurrence risk ratio (the risk of expressing the disease phenotype in siblings of the proband divided by the risk observed in the general population), the genotypic risk ratio (the risk of expressing the phenotype if the gene is present divided by the risk if the gene is not present), the number of susceptibility genes, how the susceptibility genes interact, how much of the disease risk is contributed by environmental factors, and the disease penetrance (the likelihood that the phenotype will be expressed if the gene is present).

AB - Diabetic nephropathy is a classic complex trait, whose development in a given individual reflects contributions from multiple genes and whose expression is modulated by environmental factors. Numerous genetic strategies have been used to identify common disease risk loci and genes, including candidate gene analyses, linkage analysis, transmission disequilibrium testing (a family based association test to identify linkage between a genetic marker and a biological trait or disease), and admixture mapping (also referred to as mapping by admixture linkage disequilibrium). Choosing the best genetic strategy to identify susceptibility genes in a disease is dependent on knowing whether the disorder is monogenic (the result of one gene), oligogenic (the result of a few genes), or polygenic (the result of many genes). The likelihood of finding risk loci for a disease with a putative genetic contribution is in part owing to the disease recurrence risk ratio (the risk of expressing the disease phenotype in siblings of the proband divided by the risk observed in the general population), the genotypic risk ratio (the risk of expressing the phenotype if the gene is present divided by the risk if the gene is not present), the number of susceptibility genes, how the susceptibility genes interact, how much of the disease risk is contributed by environmental factors, and the disease penetrance (the likelihood that the phenotype will be expressed if the gene is present).

KW - Admixture mapping

KW - Diabetic nephropathy risk loci

KW - Mexican-Americans

UR - http://www.scopus.com/inward/record.url?scp=77950470657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950470657&partnerID=8YFLogxK

U2 - 10.1016/j.semnephrol.2010.01.005

DO - 10.1016/j.semnephrol.2010.01.005

M3 - Article

VL - 30

SP - 141

EP - 149

JO - Seminars in Nephrology

JF - Seminars in Nephrology

SN - 0270-9295

IS - 2

ER -