MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos

Bruce W. Draper, Craig C. Mello, Bruce Bowerman, Jeff Hardin, James R. Priess

Research output: Contribution to journalArticle

194 Scopus citations

Abstract

After the first division of the C. elegans embryo, the posterior blastomere can produce numerous muscles while the anterior blastomere cannot. We show here that maternal-effect lethal mutations in the gene mex-3 cause descendants of the anterior blastomere to produce muscles by a pattern of development similar to that of a descendant of the wild-type posterior blastomere. mex-3 encodes a probable RNA-binding protein that is distributed unequally in early embryos and that is a component of germline-specific granules called P granules. We propose that MEX-3 contributes to anterior- posterior asymmetry by regulating one or more mRNAs involved in specifying the fate of the posterior blastomere.

Original languageEnglish (US)
Pages (from-to)205-216
Number of pages12
JournalCell
Volume87
Issue number2
DOIs
StatePublished - Oct 18 1996
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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    Draper, B. W., Mello, C. C., Bowerman, B., Hardin, J., & Priess, J. R. (1996). MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Cell, 87(2), 205-216. https://doi.org/10.1016/S0092-8674(00)81339-2