Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells

Javad Alizadeh, Amir A. Zeki, Nima Mirzaei, Sandipan Tewary, Adel Rezaei Moghadam, Aleksandra Glogowska, Pandian Nagakannan, Eftekhar Eftekharpour, Emilia Wiechec, Joseph W. Gordon, Fred Y. Xu, Jared T. Field, Ken Y. Yoneda, Nicholas J. Kenyon, Mohammad Hashemi, Grant M. Hatch, Sabine Hombach-Klonisch, Thomas Klonisch, Saeid Ghavami

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Medicine & Life Sciences