Metronomic chemotherapy with toceranib phosphate for treatment of a chemodectoma in a dog

Hye Ri Shin, Jun Seok Kim, Sung Min Kim, Kun Ho Song, Kyoung Won Seo

Research output: Contribution to journalArticle

Abstract

A 10-year-old, spayed, female Cocker Spaniel was referred to our hospital with a history of a cough and dyspnea. The patient was tentatively diagnosed with a chemodectoma based on clinical features evident on echocardiography and computed tomography. Metronomic chemotherapy utilizing toceranib phosphate as well as medications for congestive heart failure were administered. During the period chemotherapy was administered (nine months from the time of diagnosis), clinical improvement was noted without the development of any adverse effects. However, clinical signs recurred after chemotherapy was discontinued at the owner’s request. When the patient was reevaluated via computed tomography, it was found that the size of the mass had increased. The patient developed severe dyspnea secondary to recurrent pleural effusion and was euthanized 65 days after clinical signs reappeared. A necropsy was performed and the patient was definitively diagnosed with a chemodectoma based on histopathologic and immunohistochemical analysis. This case report describes the clinical application of metronomic chemotherapy with toceranib phosphate, which is a tyrosine kinase inhibitor, in the treatment of a chemodectoma. We propose that this treatment may improve the quality of life and result in a prolonged survival time compared to treatment with medications for congestive heart failure alone.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalJournal of Veterinary Clinics
Volume34
Issue number1
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

Fingerprint

Extra-Adrenal Paraganglioma
drug therapy
Dogs
phosphates
Drug Therapy
dogs
Dyspnea
Heart Failure
dyspnea
Tomography
heart failure
computed tomography
Pleural Effusion
Therapeutics
Cough
Protein-Tyrosine Kinases
Echocardiography
Cocker Spaniel
cough
echocardiography

Keywords

  • Chemodectoma
  • Metronomic chemotherapy
  • Toceranib phosphate
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Metronomic chemotherapy with toceranib phosphate for treatment of a chemodectoma in a dog. / Shin, Hye Ri; Kim, Jun Seok; Kim, Sung Min; Song, Kun Ho; Seo, Kyoung Won.

In: Journal of Veterinary Clinics, Vol. 34, No. 1, 01.02.2017, p. 43-46.

Research output: Contribution to journalArticle

Shin, Hye Ri ; Kim, Jun Seok ; Kim, Sung Min ; Song, Kun Ho ; Seo, Kyoung Won. / Metronomic chemotherapy with toceranib phosphate for treatment of a chemodectoma in a dog. In: Journal of Veterinary Clinics. 2017 ; Vol. 34, No. 1. pp. 43-46.
@article{cd549f7c9b904016bea304f7d9210eb2,
title = "Metronomic chemotherapy with toceranib phosphate for treatment of a chemodectoma in a dog",
abstract = "A 10-year-old, spayed, female Cocker Spaniel was referred to our hospital with a history of a cough and dyspnea. The patient was tentatively diagnosed with a chemodectoma based on clinical features evident on echocardiography and computed tomography. Metronomic chemotherapy utilizing toceranib phosphate as well as medications for congestive heart failure were administered. During the period chemotherapy was administered (nine months from the time of diagnosis), clinical improvement was noted without the development of any adverse effects. However, clinical signs recurred after chemotherapy was discontinued at the owner’s request. When the patient was reevaluated via computed tomography, it was found that the size of the mass had increased. The patient developed severe dyspnea secondary to recurrent pleural effusion and was euthanized 65 days after clinical signs reappeared. A necropsy was performed and the patient was definitively diagnosed with a chemodectoma based on histopathologic and immunohistochemical analysis. This case report describes the clinical application of metronomic chemotherapy with toceranib phosphate, which is a tyrosine kinase inhibitor, in the treatment of a chemodectoma. We propose that this treatment may improve the quality of life and result in a prolonged survival time compared to treatment with medications for congestive heart failure alone.",
keywords = "Chemodectoma, Metronomic chemotherapy, Toceranib phosphate, Tyrosine kinase inhibitor",
author = "Shin, {Hye Ri} and Kim, {Jun Seok} and Kim, {Sung Min} and Song, {Kun Ho} and Seo, {Kyoung Won}",
year = "2017",
month = "2",
day = "1",
doi = "10.17555/jvc.2017.02.34.1.43",
language = "English (US)",
volume = "34",
pages = "43--46",
journal = "Journal of Veterinary Clinics",
issn = "1598-298X",
publisher = "Korean Society of Veterinary Clinics",
number = "1",

}

TY - JOUR

T1 - Metronomic chemotherapy with toceranib phosphate for treatment of a chemodectoma in a dog

AU - Shin, Hye Ri

AU - Kim, Jun Seok

AU - Kim, Sung Min

AU - Song, Kun Ho

AU - Seo, Kyoung Won

PY - 2017/2/1

Y1 - 2017/2/1

N2 - A 10-year-old, spayed, female Cocker Spaniel was referred to our hospital with a history of a cough and dyspnea. The patient was tentatively diagnosed with a chemodectoma based on clinical features evident on echocardiography and computed tomography. Metronomic chemotherapy utilizing toceranib phosphate as well as medications for congestive heart failure were administered. During the period chemotherapy was administered (nine months from the time of diagnosis), clinical improvement was noted without the development of any adverse effects. However, clinical signs recurred after chemotherapy was discontinued at the owner’s request. When the patient was reevaluated via computed tomography, it was found that the size of the mass had increased. The patient developed severe dyspnea secondary to recurrent pleural effusion and was euthanized 65 days after clinical signs reappeared. A necropsy was performed and the patient was definitively diagnosed with a chemodectoma based on histopathologic and immunohistochemical analysis. This case report describes the clinical application of metronomic chemotherapy with toceranib phosphate, which is a tyrosine kinase inhibitor, in the treatment of a chemodectoma. We propose that this treatment may improve the quality of life and result in a prolonged survival time compared to treatment with medications for congestive heart failure alone.

AB - A 10-year-old, spayed, female Cocker Spaniel was referred to our hospital with a history of a cough and dyspnea. The patient was tentatively diagnosed with a chemodectoma based on clinical features evident on echocardiography and computed tomography. Metronomic chemotherapy utilizing toceranib phosphate as well as medications for congestive heart failure were administered. During the period chemotherapy was administered (nine months from the time of diagnosis), clinical improvement was noted without the development of any adverse effects. However, clinical signs recurred after chemotherapy was discontinued at the owner’s request. When the patient was reevaluated via computed tomography, it was found that the size of the mass had increased. The patient developed severe dyspnea secondary to recurrent pleural effusion and was euthanized 65 days after clinical signs reappeared. A necropsy was performed and the patient was definitively diagnosed with a chemodectoma based on histopathologic and immunohistochemical analysis. This case report describes the clinical application of metronomic chemotherapy with toceranib phosphate, which is a tyrosine kinase inhibitor, in the treatment of a chemodectoma. We propose that this treatment may improve the quality of life and result in a prolonged survival time compared to treatment with medications for congestive heart failure alone.

KW - Chemodectoma

KW - Metronomic chemotherapy

KW - Toceranib phosphate

KW - Tyrosine kinase inhibitor

UR - http://www.scopus.com/inward/record.url?scp=85018352819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018352819&partnerID=8YFLogxK

U2 - 10.17555/jvc.2017.02.34.1.43

DO - 10.17555/jvc.2017.02.34.1.43

M3 - Article

AN - SCOPUS:85018352819

VL - 34

SP - 43

EP - 46

JO - Journal of Veterinary Clinics

JF - Journal of Veterinary Clinics

SN - 1598-298X

IS - 1

ER -