Abstract
Two chiral quaternary carbon-containing fragments suitable for elaboration to the briaran diterpenes were obtained by regioselective methylation of functionalized 3,3-disubstituted 2,3-epoxy-1-ols. The factors which favor methylation at the more hindered position of a trisubstituted 2,3-epoxy alcohol were determined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7429-7444 |
| Number of pages | 16 |
| Journal | Tetrahedron |
| Volume | 53 |
| Issue number | 22 |
| DOIs | |
| State | Published - Jun 2 1997 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Balasubramaniam, R. P., Moss, D. K., Wyatt, J. K., Spence, J. D., Gee, A., & Nantz, M. H. (1997). Methylation-ring opening of 3,3-disubstituted 2,3-epoxy alcohols. Synthesis of chiral quaternary fragments for assembly of briaran diterpenes. Tetrahedron, 53(22), 7429-7444. https://doi.org/10.1016/S0040-4020(97)00453-5