Methotrexate and misoprostol for abortion at 57-63 days gestation

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Methotrexate and misoprostol have been shown in preliminary studies to be effective for abortion at ≤56 days gestation with minimal side effects. RU-486 is used in combination with prostaglandin for abortion ≤49 days gestation in France but ≤63 days gestation in England. This pilot study was performed to evaluate if methotrexate and misoprsotol may also be effectve up to 63 days gestation. Ten pregnant women between 57-63 days gestation were treated with methotrexate 50 mg/m2 intramuscularly followed 3 days later by misoprostol 800 μg vaginally. Abortion occurred in 6 women; abortion occurred in one of the women after a repeat dose of misoprostol 24 hours after the first dose. The remaining 4 women all had a surgical abortion. In the successfully treated women, vaginal bleeding lasted 14 ± 4 (mean ± standard deviation) days and serum β-hCG was ≤25 IU/L by 32 ± 5 days after the methotrexate injection. No methotrexate side effects occurred. Methotrexate and misoprostol do not appear to be as effective for medical abortion between 57 and 63 days gestation as compared to ≤56 days gestation.

Original languageEnglish (US)
Pages (from-to)511-515
Number of pages5
JournalContraception
Volume50
Issue number6
DOIs
StatePublished - 1994

Fingerprint

Misoprostol
Methotrexate
Pregnancy
Mifepristone
Uterine Hemorrhage
England
France
Prostaglandins
Pregnant Women
Injections
Serum

Keywords

  • Medical abortion
  • methotrexate
  • misoprostol
  • vaginal ultrasound
  • β-hCG

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Methotrexate and misoprostol for abortion at 57-63 days gestation. / Creinin, Mitchell D.

In: Contraception, Vol. 50, No. 6, 1994, p. 511-515.

Research output: Contribution to journalArticle

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abstract = "Methotrexate and misoprostol have been shown in preliminary studies to be effective for abortion at ≤56 days gestation with minimal side effects. RU-486 is used in combination with prostaglandin for abortion ≤49 days gestation in France but ≤63 days gestation in England. This pilot study was performed to evaluate if methotrexate and misoprsotol may also be effectve up to 63 days gestation. Ten pregnant women between 57-63 days gestation were treated with methotrexate 50 mg/m2 intramuscularly followed 3 days later by misoprostol 800 μg vaginally. Abortion occurred in 6 women; abortion occurred in one of the women after a repeat dose of misoprostol 24 hours after the first dose. The remaining 4 women all had a surgical abortion. In the successfully treated women, vaginal bleeding lasted 14 ± 4 (mean ± standard deviation) days and serum β-hCG was ≤25 IU/L by 32 ± 5 days after the methotrexate injection. No methotrexate side effects occurred. Methotrexate and misoprostol do not appear to be as effective for medical abortion between 57 and 63 days gestation as compared to ≤56 days gestation.",
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