Abstract
Antibodies for therapy and diagnostics make up one of the fastest growing segments of the biopharmaceutical market. This review provides an overview of methods and processes for the selection and production of therapeutic and diagnostic recombinant proteins, including monoclonal and polyclonal antibodies. This overview also includes a comparative economic summary of current and some potential expression systems for manufacture of these highly functional recombinant proteins and antibodies, and explores the future direction of the antibody industry.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-219 |
| Number of pages | 21 |
| Journal | Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry |
| Volume | 11 |
| Issue number | 3 |
| State | Published - Sep 2011 |
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Keywords
- Antibodies
- Antibody production
- Biosimilars
- Comparative economics
- Downstream processing
- Expression pathways
- Immunotherapeutics
- Monoclonal and polyclonal antibody production
- Operational excellence
- Process efficiency improvement
- Recombinant proteins
- Six-sigma
- Smart systems
- Therapeutic protein production
- Yield economics
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Pharmacology
Cite this
Methods, processes and comparative yield economics for the production of antibodies and recombinant proteins. / Paradise, William A.; Vesper, Benjamin J.; Babich, Michael; Colvard, Michael D.; Radosevich, James A.
In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, Vol. 11, No. 3, 09.2011, p. 199-219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Methods, processes and comparative yield economics for the production of antibodies and recombinant proteins
AU - Paradise, William A.
AU - Vesper, Benjamin J.
AU - Babich, Michael
AU - Colvard, Michael D.
AU - Radosevich, James A.
PY - 2011/9
Y1 - 2011/9
N2 - Antibodies for therapy and diagnostics make up one of the fastest growing segments of the biopharmaceutical market. This review provides an overview of methods and processes for the selection and production of therapeutic and diagnostic recombinant proteins, including monoclonal and polyclonal antibodies. This overview also includes a comparative economic summary of current and some potential expression systems for manufacture of these highly functional recombinant proteins and antibodies, and explores the future direction of the antibody industry.
AB - Antibodies for therapy and diagnostics make up one of the fastest growing segments of the biopharmaceutical market. This review provides an overview of methods and processes for the selection and production of therapeutic and diagnostic recombinant proteins, including monoclonal and polyclonal antibodies. This overview also includes a comparative economic summary of current and some potential expression systems for manufacture of these highly functional recombinant proteins and antibodies, and explores the future direction of the antibody industry.
KW - Antibodies
KW - Antibody production
KW - Biosimilars
KW - Comparative economics
KW - Downstream processing
KW - Expression pathways
KW - Immunotherapeutics
KW - Monoclonal and polyclonal antibody production
KW - Operational excellence
KW - Process efficiency improvement
KW - Recombinant proteins
KW - Six-sigma
KW - Smart systems
KW - Therapeutic protein production
KW - Yield economics
UR - http://www.scopus.com/inward/record.url?scp=80051765384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051765384&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:80051765384
VL - 11
SP - 199
EP - 219
JO - Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
JF - Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
SN - 1871-5222
IS - 3
ER -