Methods, processes and comparative yield economics for the production of antibodies and recombinant proteins

William A. Paradise; Benjamin J. Vesper; Michael Babich; Michael D. Colvard; James A. Radosevich

Methods, processes and comparative yield economics for the production of antibodies and recombinant proteins

William A. Paradise, Benjamin J. Vesper, Michael Babich, Michael D. Colvard, James A. Radosevich

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Antibodies for therapy and diagnostics make up one of the fastest growing segments of the biopharmaceutical market. This review provides an overview of methods and processes for the selection and production of therapeutic and diagnostic recombinant proteins, including monoclonal and polyclonal antibodies. This overview also includes a comparative economic summary of current and some potential expression systems for manufacture of these highly functional recombinant proteins and antibodies, and explores the future direction of the antibody industry.

Original language	English (US)
Pages (from-to)	199-219
Number of pages	21
Journal	Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume	11
Issue number	3
State	Published - Sep 2011

Keywords

Antibodies
Antibody production
Biosimilars
Comparative economics
Downstream processing
Expression pathways
Immunotherapeutics
Monoclonal and polyclonal antibody production
Operational excellence
Process efficiency improvement
Recombinant proteins
Six-sigma
Smart systems
Therapeutic protein production
Yield economics

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Pharmacology

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Methods, processes and comparative yield economics for the production of antibodies and recombinant proteins. / Paradise, William A.; Vesper, Benjamin J.; Babich, Michael; Colvard, Michael D.; Radosevich, James A.

In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, Vol. 11, No. 3, 09.2011, p. 199-219.

Research output: Contribution to journal › Article › peer-review

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abstract = "Antibodies for therapy and diagnostics make up one of the fastest growing segments of the biopharmaceutical market. This review provides an overview of methods and processes for the selection and production of therapeutic and diagnostic recombinant proteins, including monoclonal and polyclonal antibodies. This overview also includes a comparative economic summary of current and some potential expression systems for manufacture of these highly functional recombinant proteins and antibodies, and explores the future direction of the antibody industry.",

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AU - Paradise, William A.

AU - Vesper, Benjamin J.

AU - Babich, Michael

AU - Colvard, Michael D.

AU - Radosevich, James A.

PY - 2011/9

Y1 - 2011/9

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AB - Antibodies for therapy and diagnostics make up one of the fastest growing segments of the biopharmaceutical market. This review provides an overview of methods and processes for the selection and production of therapeutic and diagnostic recombinant proteins, including monoclonal and polyclonal antibodies. This overview also includes a comparative economic summary of current and some potential expression systems for manufacture of these highly functional recombinant proteins and antibodies, and explores the future direction of the antibody industry.

KW - Antibodies

KW - Antibody production

KW - Biosimilars

KW - Comparative economics

KW - Downstream processing

KW - Expression pathways

KW - Immunotherapeutics

KW - Monoclonal and polyclonal antibody production

KW - Operational excellence

KW - Process efficiency improvement

KW - Recombinant proteins

KW - Six-sigma

KW - Smart systems

KW - Therapeutic protein production

KW - Yield economics

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AN - SCOPUS:80051765384

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JO - Current Medicinal Chemistry: Immunology, Endocrine and Metabolic Agents

JF - Current Medicinal Chemistry: Immunology, Endocrine and Metabolic Agents

SN - 1871-5222

IS - 3

ER -

Methods, processes and comparative yield economics for the production of antibodies and recombinant proteins

Abstract

Keywords

ASJC Scopus subject areas

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