Methods, processes and comparative yield economics for the production of antibodies and recombinant proteins

William A. Paradise, Benjamin J. Vesper, Michael Babich, Michael D. Colvard, James A. Radosevich

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Antibodies for therapy and diagnostics make up one of the fastest growing segments of the biopharmaceutical market. This review provides an overview of methods and processes for the selection and production of therapeutic and diagnostic recombinant proteins, including monoclonal and polyclonal antibodies. This overview also includes a comparative economic summary of current and some potential expression systems for manufacture of these highly functional recombinant proteins and antibodies, and explores the future direction of the antibody industry.

Original languageEnglish (US)
Pages (from-to)199-219
Number of pages21
JournalImmunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume11
Issue number3
StatePublished - Sep 2011

Keywords

  • Antibodies
  • Antibody production
  • Biosimilars
  • Comparative economics
  • Downstream processing
  • Expression pathways
  • Immunotherapeutics
  • Monoclonal and polyclonal antibody production
  • Operational excellence
  • Process efficiency improvement
  • Recombinant proteins
  • Six-sigma
  • Smart systems
  • Therapeutic protein production
  • Yield economics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Pharmacology

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