Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images

Charles DeCarli, J. Maisog, D. G M Murphy, D. Teichberg, S. I. Rapoport, B. Horwitz

Research output: Contribution to journalArticle

236 Scopus citations

Abstract

We describe a simple, rapid, and semiautomated method of MR analysis based on mathematical modeling of MR pixel intensity histograms. The method is shown to be accurate and reliable for regional analysis of brain, central, and subarachnoid CSF volumes. Application of the method to five young and six older subjects revealed significant age-related changes in regional brain volumes whereas no difference was found for traced central CSF volumes or subarachnoid CSF volumes. We conclude that this is a simple method that can be applied to further studies of quantification of brain structure in healthy aging and brain disease.

Original languageEnglish (US)
Pages (from-to)274-284
Number of pages11
JournalJournal of Computer Assisted Tomography
Volume16
Issue number2
StatePublished - 1992
Externally publishedYes

Keywords

  • Aging
  • Brain, volume
  • Magnetic resonance imaging, techniques

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    DeCarli, C., Maisog, J., Murphy, D. G. M., Teichberg, D., Rapoport, S. I., & Horwitz, B. (1992). Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. Journal of Computer Assisted Tomography, 16(2), 274-284.