Abstract
We describe a simple, rapid, and semiautomated method of MR analysis based on mathematical modeling of MR pixel intensity histograms. The method is shown to be accurate and reliable for regional analysis of brain, central, and subarachnoid CSF volumes. Application of the method to five young and six older subjects revealed significant age-related changes in regional brain volumes whereas no difference was found for traced central CSF volumes or subarachnoid CSF volumes. We conclude that this is a simple method that can be applied to further studies of quantification of brain structure in healthy aging and brain disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 274-284 |
| Number of pages | 11 |
| Journal | Journal of Computer Assisted Tomography |
| Volume | 16 |
| Issue number | 2 |
| State | Published - 1992 |
| Externally published | Yes |
Keywords
- Aging
- Brain, volume
- Magnetic resonance imaging, techniques
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
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DeCarli, C., Maisog, J., Murphy, D. G. M., Teichberg, D., Rapoport, S. I., & Horwitz, B. (1992). Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. Journal of Computer Assisted Tomography, 16(2), 274-284.