Method for dissecting the auditory epithelium (basilar papilla) in developing chick embryos

Snezana Levic, Ebenezer N. Yamoah

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chickens are an invaluable model for exploring auditory physiology. Similar to humans, the chicken inner ear is morphologically and functionally close to maturity at the time of hatching. In contrast, chicks can regenerate hearing, an ability lost in all mammals, including humans. The extensive morphological, physiological, behavioral, and pharmacological data available, regarding normal development in the chicken auditory system, has driven the progress of the field. The basilar papilla is an attractive model system to study the developmental mechanisms of hearing. Here, we describe the dissection technique for isolating the basilar papilla in developing chick inner ear. We also provide detailed examples of physiological (patch clamping) experiments using this preparation.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages463-470
Number of pages8
Volume1427
DOIs
StatePublished - 2016
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1427
ISSN (Print)10643745

Keywords

  • Basilar papilla
  • Development
  • Hair cells
  • Patch clamping

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Levic, S., & Yamoah, E. N. (2016). Method for dissecting the auditory epithelium (basilar papilla) in developing chick embryos. In Methods in Molecular Biology (Vol. 1427, pp. 463-470). (Methods in Molecular Biology; Vol. 1427). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3615-1_25