Methadone reincarnated: Novel clinical applications with related concerns

Scott M Fishman, Barth Wilsey, Gagan Mahajan, Patricia Molina

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Methadone has numerous advantages as an analgesic, which have supported its recent increase in use. However, methadone also has a pharmacological profile as an opioid that differentiates it from other, better known or more widely used opioids. It also has unusual pharmacodynamics, pharmacokinetics, and metabolism that must be considered for safe use of methadone as an analgesic. This review looks at the history of methadone use as an analgesic and its properties that distinguish it as an unusual, and potentially, unstable opioid.

Original languageEnglish (US)
Pages (from-to)339-348
Number of pages10
JournalPain Medicine
Volume3
Issue number4
DOIs
StatePublished - 2002

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Keywords

  • Analgesia
  • Drug interactions
  • Methadone
  • Neuropathic
  • Opioid
  • Pain
  • Rotation
  • Tolerance

ASJC Scopus subject areas

  • Clinical Neurology

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