Methadone reincarnated: Novel clinical applications with related concerns

Scott M Fishman, Barth Wilsey, Gagan Mahajan, Patricia Molina

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Methadone has numerous advantages as an analgesic, which have supported its recent increase in use. However, methadone also has a pharmacological profile as an opioid that differentiates it from other, better known or more widely used opioids. It also has unusual pharmacodynamics, pharmacokinetics, and metabolism that must be considered for safe use of methadone as an analgesic. This review looks at the history of methadone use as an analgesic and its properties that distinguish it as an unusual, and potentially, unstable opioid.

Original languageEnglish (US)
Pages (from-to)339-348
Number of pages10
JournalPain Medicine
Issue number4
StatePublished - 2002


  • Analgesia
  • Drug interactions
  • Methadone
  • Neuropathic
  • Opioid
  • Pain
  • Rotation
  • Tolerance

ASJC Scopus subject areas

  • Clinical Neurology


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